PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment
Introduction: The complex and multidimensional nature of pain poses a major challenge in clinical pain assessments. In this study, we aimed to evaluate a novel approach combining quantitative sensory testing (QST) with event-related potential measurements for assessment of experimental pain in healt...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1197070/full |
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| author | Li Chen Zhen Zhang Rui Han Liyuan Du Zhenxing Li Shuiping Liu Dong Huang Dong Huang Haocheng Zhou Haocheng Zhou |
| author_facet | Li Chen Zhen Zhang Rui Han Liyuan Du Zhenxing Li Shuiping Liu Dong Huang Dong Huang Haocheng Zhou Haocheng Zhou |
| author_sort | Li Chen |
| collection | DOAJ |
| description | Introduction: The complex and multidimensional nature of pain poses a major challenge in clinical pain assessments. In this study, we aimed to evaluate a novel approach combining quantitative sensory testing (QST) with event-related potential measurements for assessment of experimental pain in healthy individuals.Methods: QST was performed with a commercial device (PainVision, PS-2100), and numeric rating scale (NRS) scores after exposure to different sensory stimuli were reported by the participants. Resting-state electroencephalography (EEG) was simultaneously performed to capture the cortical responses to peripheral stimulation.Results: Pain scores increased with the intensity of stimuli, with mean NRS scores of 2.7 ± 1.0 after mild stimuli and 5.6 ± 1.0 after moderate stimuli. A reproducible, significant P2-N2 complex was evoked by both mild and moderately painful stimuli, but not by non-painful stimuli. The latency of pain-related potentials was not significantly different between stimuli. The amplitudes of both P2 and N2 components significantly increased when intense nociception was applied, and the increments mainly originated from theta oscillations.Conclusion: The combination of QST with EEG was feasible for subjective and objective pain assessment. Distinct patterns of brain potentials were associated with the phenotype of the peripheral stimuli (e.g., noxious versus. innoxious, high versus. low pain intensity). |
| first_indexed | 2024-03-13T02:34:04Z |
| format | Article |
| id | doaj.art-373d4cc89e78439cbe1f1f3e56ce99e4 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-13T02:34:04Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-373d4cc89e78439cbe1f1f3e56ce99e42023-06-29T09:19:39ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-06-011110.3389/fbioe.2023.11970701197070PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessmentLi Chen0Zhen Zhang1Rui Han2Liyuan Du3Zhenxing Li4Shuiping Liu5Dong Huang6Dong Huang7Haocheng Zhou8Haocheng Zhou9Department of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaDepartment of Pain, Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Brain Homeostasis, Central South University, Changsha, ChinaDepartment of Pain, The Third Xiangya Hospital and Institute of Pain Medicine, Central South University, Changsha, ChinaHunan Key Laboratory of Brain Homeostasis, Central South University, Changsha, ChinaIntroduction: The complex and multidimensional nature of pain poses a major challenge in clinical pain assessments. In this study, we aimed to evaluate a novel approach combining quantitative sensory testing (QST) with event-related potential measurements for assessment of experimental pain in healthy individuals.Methods: QST was performed with a commercial device (PainVision, PS-2100), and numeric rating scale (NRS) scores after exposure to different sensory stimuli were reported by the participants. Resting-state electroencephalography (EEG) was simultaneously performed to capture the cortical responses to peripheral stimulation.Results: Pain scores increased with the intensity of stimuli, with mean NRS scores of 2.7 ± 1.0 after mild stimuli and 5.6 ± 1.0 after moderate stimuli. A reproducible, significant P2-N2 complex was evoked by both mild and moderately painful stimuli, but not by non-painful stimuli. The latency of pain-related potentials was not significantly different between stimuli. The amplitudes of both P2 and N2 components significantly increased when intense nociception was applied, and the increments mainly originated from theta oscillations.Conclusion: The combination of QST with EEG was feasible for subjective and objective pain assessment. Distinct patterns of brain potentials were associated with the phenotype of the peripheral stimuli (e.g., noxious versus. innoxious, high versus. low pain intensity).https://www.frontiersin.org/articles/10.3389/fbioe.2023.1197070/fullpain assessmentquantitative sensory testingPainVisionevent-related potentialEEG |
| spellingShingle | Li Chen Zhen Zhang Rui Han Liyuan Du Zhenxing Li Shuiping Liu Dong Huang Dong Huang Haocheng Zhou Haocheng Zhou PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment Frontiers in Bioengineering and Biotechnology pain assessment quantitative sensory testing PainVision event-related potential EEG |
| title | PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment |
| title_full | PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment |
| title_fullStr | PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment |
| title_full_unstemmed | PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment |
| title_short | PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment |
| title_sort | painvision based evaluation of brain potentials a novel approach for quantitative pain assessment |
| topic | pain assessment quantitative sensory testing PainVision event-related potential EEG |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1197070/full |
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