Atroposelective Amination of Indoles via Chiral Center Induced Chiral Axis Formation

Atroposelective Amination of Indoles via Chiral Center Induced Chiral Axis Formation

The construction of an N–C chiral axis for N-aryl indole derivatives is meaningful as they widely exist in functionalized molecules. This work provides a novel method for this purpose via amination of amino acid derivatives at the C2 position of the indole and chiral center induced chiral axis forma...

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Bibliographic Details
Main Authors: Yong Wang, Jingxue Yan, Yiqing Jiang, Zexuan Wei, Zhenlin Tu, Chao Dong, Tao Lu, Yadong Chen, Jie Feng
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
central-to-axial
amination
atropisomers
indole skeleton
amino acid
Online Access:https://www.mdpi.com/1420-3049/27/24/9008

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