Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence

Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence

Irreparable double-strand breaks (DSBs) in response to ionizing radiation (IR) trigger prolonged DNA damage response (DDR) and induce premature senescence. Profound chromatin reorganization with formation of senescence-associated heterochromatin foci (SAHF) is an essential epigenetic mechanism for c...

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Bibliographic Details
Main Authors: Anna Isermann, Carl Mann, Claudia E. Rübe
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
histone variant H2A.J
radiation-induced senescence
senescence-associated heterochromatin foci (SAHF)
DNA-SCARS
transmission electron microscopy (TEM)
senescence-associated secretory phenotype (SASP)
Online Access:https://www.mdpi.com/1422-0067/21/23/9130

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