Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study
The purpose of the study was to characterize lower extremity peripheral arterial disease (LEPAD) in a series of kidney transplant patients and to assess the impact on adverse outcomes. A retrospective cohort study was conducted including kidney transplant recipient patients who underwent screening f...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Transplantology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-3943/4/3/12 |
| _version_ | 1797576468290600960 |
|---|---|
| author | Luis Carlos Alvarez-Perdomo John Ubeimar Cataño-Bedoya Maribel Plaza-Tenorio Ana María Botero-Mora Isabel del Pilar Cardozo-Moreno Luis Manuel Barrera-Lozano Jaime Alberto Ramírez-Arbeláez Carlos M. Ardila |
| author_facet | Luis Carlos Alvarez-Perdomo John Ubeimar Cataño-Bedoya Maribel Plaza-Tenorio Ana María Botero-Mora Isabel del Pilar Cardozo-Moreno Luis Manuel Barrera-Lozano Jaime Alberto Ramírez-Arbeláez Carlos M. Ardila |
| author_sort | Luis Carlos Alvarez-Perdomo |
| collection | DOAJ |
| description | The purpose of the study was to characterize lower extremity peripheral arterial disease (LEPAD) in a series of kidney transplant patients and to assess the impact on adverse outcomes. A retrospective cohort study was conducted including kidney transplant recipient patients who underwent screening for LEPAD. The outcomes evaluated were classified as perioperative and post-transplant, including cardiovascular events, amputation, mortality, and loss of the graft. A total of 141 renal transplant patients screened for LEPAD were identified, with an average follow-up of 3 years. LEPAD occurred in 14.2% (20/141). No differences in cardiovascular risk factors were found between the groups, except for smoking (45% vs. 24%, <i>p</i> < 0.05). In the group with LEPAD, the most compromised anatomical segment was the infrapopliteus, with no iliac involvement found. The Cox proportional hazards model indicated that the variables age, gender, and weight were significant in patients with LEPAD. There were no differences between the groups in terms of graft loss and death. The infrapopliteal segment is the area of greatest stenosis in kidney transplant patients with LEPAD. Together with smoking, they can explain the presence of major amputations in kidney transplant patients; however, they had no impact on graft functionality or death. |
| first_indexed | 2024-03-10T21:53:25Z |
| format | Article |
| id | doaj.art-374138be71a7434a84f4f68b4b73caed |
| institution | Directory Open Access Journal |
| issn | 2673-3943 |
| language | English |
| last_indexed | 2024-03-10T21:53:25Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Transplantology |
| spelling | doaj.art-374138be71a7434a84f4f68b4b73caed2023-11-19T13:16:26ZengMDPI AGTransplantology2673-39432023-07-014311112310.3390/transplantology4030012Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort StudyLuis Carlos Alvarez-Perdomo0John Ubeimar Cataño-Bedoya1Maribel Plaza-Tenorio2Ana María Botero-Mora3Isabel del Pilar Cardozo-Moreno4Luis Manuel Barrera-Lozano5Jaime Alberto Ramírez-Arbeláez6Carlos M. Ardila7Vascular Medicine Department, Faculty of Medicine, Universidad de Antioquia UdeA, Medellín 050010, ColombiaVascular Medicine Department, Faculty of Medicine, Universidad de Antioquia UdeA, Medellín 050010, ColombiaVascular Medicine Department, Hospital San Vicente Fundación, Rionegro 054047, ColombiaVascular Surgery Department, Hospital San Vicente Fundación, Rionegro 054047, ColombiaSurgery Department, Universidad Sur Colombiana, Neiva 059046, ColombiaVascular Medicine Department, Faculty of Medicine, Universidad de Antioquia UdeA, Medellín 050010, ColombiaTransplant Department, Hospital San Vicente Fundación, Rionegro 054047, ColombiaBasic Studies Department, FdeO Universidad de Antioquia UdeA, Medellín 050010, ColombiaThe purpose of the study was to characterize lower extremity peripheral arterial disease (LEPAD) in a series of kidney transplant patients and to assess the impact on adverse outcomes. A retrospective cohort study was conducted including kidney transplant recipient patients who underwent screening for LEPAD. The outcomes evaluated were classified as perioperative and post-transplant, including cardiovascular events, amputation, mortality, and loss of the graft. A total of 141 renal transplant patients screened for LEPAD were identified, with an average follow-up of 3 years. LEPAD occurred in 14.2% (20/141). No differences in cardiovascular risk factors were found between the groups, except for smoking (45% vs. 24%, <i>p</i> < 0.05). In the group with LEPAD, the most compromised anatomical segment was the infrapopliteus, with no iliac involvement found. The Cox proportional hazards model indicated that the variables age, gender, and weight were significant in patients with LEPAD. There were no differences between the groups in terms of graft loss and death. The infrapopliteal segment is the area of greatest stenosis in kidney transplant patients with LEPAD. Together with smoking, they can explain the presence of major amputations in kidney transplant patients; however, they had no impact on graft functionality or death.https://www.mdpi.com/2673-3943/4/3/12peripheral arterial diseasephotoplethysmographykidney transplantankle-brachial indextoe-brachial indexamputation |
| spellingShingle | Luis Carlos Alvarez-Perdomo John Ubeimar Cataño-Bedoya Maribel Plaza-Tenorio Ana María Botero-Mora Isabel del Pilar Cardozo-Moreno Luis Manuel Barrera-Lozano Jaime Alberto Ramírez-Arbeláez Carlos M. Ardila Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study Transplantology peripheral arterial disease photoplethysmography kidney transplant ankle-brachial index toe-brachial index amputation |
| title | Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study |
| title_full | Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study |
| title_fullStr | Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study |
| title_full_unstemmed | Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study |
| title_short | Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study |
| title_sort | lower extremity peripheral arterial disease and its relationship with adverse outcomes in kidney transplant recipients a retrospective cohort study |
| topic | peripheral arterial disease photoplethysmography kidney transplant ankle-brachial index toe-brachial index amputation |
| url | https://www.mdpi.com/2673-3943/4/3/12 |
| work_keys_str_mv | AT luiscarlosalvarezperdomo lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT johnubeimarcatanobedoya lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT maribelplazatenorio lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT anamariaboteromora lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT isabeldelpilarcardozomoreno lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT luismanuelbarreralozano lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT jaimealbertoramirezarbelaez lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy AT carlosmardila lowerextremityperipheralarterialdiseaseanditsrelationshipwithadverseoutcomesinkidneytransplantrecipientsaretrospectivecohortstudy |