Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed
Protection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2020-08-01
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| Series: | Interventional Cardiology: Reviews, Research, Resources |
| Online Access: | https://www.icrjournal.com/articles/cardioprotection-for-acute-mi-in-light |
| _version_ | 1797200034922496000 |
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| author | Joel P Giblett Heerajnarain Bulluck |
| author_facet | Joel P Giblett Heerajnarain Bulluck |
| author_sort | Joel P Giblett |
| collection | DOAJ |
| description | Protection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention (CONDI2/ERIC-PPCI) trial to show translation to clinical benefit, there is still no pharmacological or mechanical strategy that has translated to clinical practice. This article addresses the results of the CONDI2/ERIC-PPCI trial in the context of previous studies of ischaemic conditioning, and then considers the prospects for other potential targets of cardioprotection. Finally, the authors examine the pitfalls and challenges in trial design for future investigation of cardioprotective strategies. In particular, this article highlights the need for careful endpoint and patient selection, as well as the need to pay attention to the biology of cardioprotection during the study. |
| first_indexed | 2024-03-07T17:40:42Z |
| format | Article |
| id | doaj.art-3741efb2e11b441eba1d4af3de1e62cf |
| institution | Directory Open Access Journal |
| issn | 1756-1477 1756-1485 |
| language | English |
| last_indexed | 2024-04-24T07:25:14Z |
| publishDate | 2020-08-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Interventional Cardiology: Reviews, Research, Resources |
| spelling | doaj.art-3741efb2e11b441eba1d4af3de1e62cf2024-04-20T16:01:56ZengRadcliffe Medical MediaInterventional Cardiology: Reviews, Research, Resources1756-14771756-14852020-08-011510.15420/icr.2020.01Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets NeededJoel P Giblett0Heerajnarain Bulluck1Department of Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UKDepartment of Cardiology, Norfolk and Norwich University Hospital, Norwich, UKProtection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention (CONDI2/ERIC-PPCI) trial to show translation to clinical benefit, there is still no pharmacological or mechanical strategy that has translated to clinical practice. This article addresses the results of the CONDI2/ERIC-PPCI trial in the context of previous studies of ischaemic conditioning, and then considers the prospects for other potential targets of cardioprotection. Finally, the authors examine the pitfalls and challenges in trial design for future investigation of cardioprotective strategies. In particular, this article highlights the need for careful endpoint and patient selection, as well as the need to pay attention to the biology of cardioprotection during the study.https://www.icrjournal.com/articles/cardioprotection-for-acute-mi-in-light |
| spellingShingle | Joel P Giblett Heerajnarain Bulluck Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed Interventional Cardiology: Reviews, Research, Resources |
| title | Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed |
| title_full | Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed |
| title_fullStr | Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed |
| title_full_unstemmed | Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed |
| title_short | Cardioprotection for Acute MI in Light of the CONDI2/ERIC-PPCI Trial: New Targets Needed |
| title_sort | cardioprotection for acute mi in light of the condi2 eric ppci trial new targets needed |
| url | https://www.icrjournal.com/articles/cardioprotection-for-acute-mi-in-light |
| work_keys_str_mv | AT joelpgiblett cardioprotectionforacutemiinlightofthecondi2ericppcitrialnewtargetsneeded AT heerajnarainbulluck cardioprotectionforacutemiinlightofthecondi2ericppcitrialnewtargetsneeded |