Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.
Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical app...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3174170?pdf=render |
| _version_ | 1818129300936720384 |
|---|---|
| author | Dana M Brantley-Sieders Aixiang Jiang Krishna Sarma Akosua Badu-Nkansah Debra L Walter Yu Shyr Jin Chen |
| author_facet | Dana M Brantley-Sieders Aixiang Jiang Krishna Sarma Akosua Badu-Nkansah Debra L Walter Yu Shyr Jin Chen |
| author_sort | Dana M Brantley-Sieders |
| collection | DOAJ |
| description | Pre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated eph and ephrin expression in human breast cancer relative to endpoints of overall and/or recurrence-free survival in large microarray datasets. We also investigated protein expression in commercial human breast tissue microarrays (TMA) and Stage I prognostic TMAs linked to recurrence outcome data. We found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets. Protein expression in TMAs supported these trends. While observed no correlation between ephrin ligand expression and clinical outcome in microarray datasets, ephrin-A1 and EphA2 protein co-expression was significantly associated with recurrence in Stage I prognostic breast cancer TMAs. Our data suggest that several Eph family members are clinically relevant and tractable targets for intervention in human breast cancer. Moreover, profiling Eph receptor expression patterns in the context of relevant ligands and in the context of stage may be valuable in terms of diagnostics and treatment. |
| first_indexed | 2024-12-11T07:46:58Z |
| format | Article |
| id | doaj.art-3741f61fe62647749f16ab646d3b52ca |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T07:46:58Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3741f61fe62647749f16ab646d3b52ca2022-12-22T01:15:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2442610.1371/journal.pone.0024426Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.Dana M Brantley-SiedersAixiang JiangKrishna SarmaAkosua Badu-NkansahDebra L WalterYu ShyrJin ChenPre-clinical studies provide compelling evidence that Eph family receptor tyrosine kinases (RTKs) and ligands promote cancer growth, neovascularization, invasion, and metastasis. Tumor suppressive roles have also been reported for the receptors, however, creating a potential barrier for clinical application. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. We investigated eph and ephrin expression in human breast cancer relative to endpoints of overall and/or recurrence-free survival in large microarray datasets. We also investigated protein expression in commercial human breast tissue microarrays (TMA) and Stage I prognostic TMAs linked to recurrence outcome data. We found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets. Protein expression in TMAs supported these trends. While observed no correlation between ephrin ligand expression and clinical outcome in microarray datasets, ephrin-A1 and EphA2 protein co-expression was significantly associated with recurrence in Stage I prognostic breast cancer TMAs. Our data suggest that several Eph family members are clinically relevant and tractable targets for intervention in human breast cancer. Moreover, profiling Eph receptor expression patterns in the context of relevant ligands and in the context of stage may be valuable in terms of diagnostics and treatment.http://europepmc.org/articles/PMC3174170?pdf=render |
| spellingShingle | Dana M Brantley-Sieders Aixiang Jiang Krishna Sarma Akosua Badu-Nkansah Debra L Walter Yu Shyr Jin Chen Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS ONE |
| title | Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. |
| title_full | Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. |
| title_fullStr | Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. |
| title_full_unstemmed | Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. |
| title_short | Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. |
| title_sort | eph ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome |
| url | http://europepmc.org/articles/PMC3174170?pdf=render |
| work_keys_str_mv | AT danambrantleysieders ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome AT aixiangjiang ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome AT krishnasarma ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome AT akosuabadunkansah ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome AT debralwalter ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome AT yushyr ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome AT jinchen ephephrinprofilinginhumanbreastcancerrevealssignificantassociationsbetweenexpressionlevelandclinicaloutcome |