Single‐cell transcriptomics provides insights into the origin and microenvironment of human oesophageal high‐grade intraepithelial neoplasia

Single‐cell transcriptomics provides insights into the origin and microenvironment of human oesophageal high‐grade intraepithelial neoplasia

Abstract Background High‐grade intraepithelial neoplasia (HIN) is the precursor of oesophageal squamous cell carcinoma. The molecular and functional properties of HIN are determined by intrinsic origin cells and the extrinsic microenvironment. Yet, these factors are poorly understood. Methods We per...

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Bibliographic Details
Main Authors: Guobin Liao, Nan Dai, Tiantian Xiong, Liang Wang, Xinwei Diao, Zhizhen Xu, Yuanli Ni, Dingrong Chen, Airui Jiang, Hui Lin, Shuangshuang Dai, Jianying Bai
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Clinical and Translational Medicine
Subjects:
heterogeneity
high‐grade intraepithelial neoplasia
single‐cell RNA sequencing
tumour origin
Online Access:https://doi.org/10.1002/ctm2.874

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