Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation
According to recent studies and observations in clinical practice, uterine fibroids increase the risk of preterm birth. There are several theories on the pathogenesis of preterm birth in the presence of fibroids. One theory proclaims that fibroid necrosis leads to preterm birth, though pathophysiolo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8064 |
| _version_ | 1797432897685159936 |
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| author | Emma E. Don Anadeijda J. E. M. C. Landman Guus Vissers Ekaterina S. Jordanova Emiel D. Post Uiterweer Christianne J. M. de Groot Marjon A. de Boer Judith A. F. Huirne |
| author_facet | Emma E. Don Anadeijda J. E. M. C. Landman Guus Vissers Ekaterina S. Jordanova Emiel D. Post Uiterweer Christianne J. M. de Groot Marjon A. de Boer Judith A. F. Huirne |
| author_sort | Emma E. Don |
| collection | DOAJ |
| description | According to recent studies and observations in clinical practice, uterine fibroids increase the risk of preterm birth. There are several theories on the pathogenesis of preterm birth in the presence of fibroids. One theory proclaims that fibroid necrosis leads to preterm birth, though pathophysiological mechanisms have not been described. Necrotic tissue secretes specific cytokines and proteins and we suggest these to be comparable to the inflammatory response leading to spontaneous preterm birth. We hypothesize that fibroid necrosis could induce preterm parturition through a similar inflammatory response. This new hypothesis generates novel perspectives for future research and the development of preventative strategies for preterm birth. Moreover, we emphasize the importance of the recognition of fibroids and especially fibroid necrosis by clinicians during pregnancy. |
| first_indexed | 2024-03-09T10:08:24Z |
| format | Article |
| id | doaj.art-3743dabb0328423488f17bf3b0f49d60 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:08:24Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3743dabb0328423488f17bf3b0f49d602023-12-01T22:56:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315806410.3390/ijms23158064Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and InflammationEmma E. Don0Anadeijda J. E. M. C. Landman1Guus Vissers2Ekaterina S. Jordanova3Emiel D. Post Uiterweer4Christianne J. M. de Groot5Marjon A. de Boer6Judith A. F. Huirne7Department of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsCenter for Gynecologic Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsDepartment of Obstetrics and Gynaecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The NetherlandsAccording to recent studies and observations in clinical practice, uterine fibroids increase the risk of preterm birth. There are several theories on the pathogenesis of preterm birth in the presence of fibroids. One theory proclaims that fibroid necrosis leads to preterm birth, though pathophysiological mechanisms have not been described. Necrotic tissue secretes specific cytokines and proteins and we suggest these to be comparable to the inflammatory response leading to spontaneous preterm birth. We hypothesize that fibroid necrosis could induce preterm parturition through a similar inflammatory response. This new hypothesis generates novel perspectives for future research and the development of preventative strategies for preterm birth. Moreover, we emphasize the importance of the recognition of fibroids and especially fibroid necrosis by clinicians during pregnancy.https://www.mdpi.com/1422-0067/23/15/8064degenerationinflammationnecrosispregnancypremature laborpreterm birth |
| spellingShingle | Emma E. Don Anadeijda J. E. M. C. Landman Guus Vissers Ekaterina S. Jordanova Emiel D. Post Uiterweer Christianne J. M. de Groot Marjon A. de Boer Judith A. F. Huirne Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation International Journal of Molecular Sciences degeneration inflammation necrosis pregnancy premature labor preterm birth |
| title | Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation |
| title_full | Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation |
| title_fullStr | Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation |
| title_full_unstemmed | Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation |
| title_short | Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation |
| title_sort | uterine fibroids causing preterm birth a new pathophysiological hypothesis on the role of fibroid necrosis and inflammation |
| topic | degeneration inflammation necrosis pregnancy premature labor preterm birth |
| url | https://www.mdpi.com/1422-0067/23/15/8064 |
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