Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Abstract Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD). However, the specific mechanism of NLRP1 inflammasome in...

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Bibliographic Details
Main Authors: Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li, Weizu Li
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Behavioral and Brain Functions
Subjects:
Alzheimer's disease
NLRP1 inflammasome
AMPK/mTOR
Autophagy
APP/PS1 mice
Online Access:https://doi.org/10.1186/s12993-023-00209-8

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