Analysis of two different tandem repetitive elements within the human apolipoprotein B gene.
A large number of copies of the sequence (dTG-dAC)n, where n is between 10 and 60, exist in the human genome, and many are useful as polymorphic markers. One of these sequences occurs about 3 kilobases 5‘ of the human apolipoprotein (apo) B gene as seven distinguishable alleles containing from (TG)1...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1991-02-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752042098X |
| _version_ | 1818727117467156480 |
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| author | EH Ludwig K Haubold BJ McCarthy |
| author_facet | EH Ludwig K Haubold BJ McCarthy |
| author_sort | EH Ludwig |
| collection | DOAJ |
| description | A large number of copies of the sequence (dTG-dAC)n, where n is between 10 and 60, exist in the human genome, and many are useful as polymorphic markers. One of these sequences occurs about 3 kilobases 5‘ of the human apolipoprotein (apo) B gene as seven distinguishable alleles containing from (TG)12 to (TG)18. This repeat is also present in the DNA of other primates. A second alternating purine-pyrimidine sequence with nine dinucleotide repeats and located in intron 4 is not polymorphic. Together with the apoB hypervariable repeat immediately 3‘ of the gene, the (TG)n sequence will provide a useful haplotype marker capable of distinguishing a large number of human apoB alleles, some of which may be associated with disease states. |
| first_indexed | 2024-12-17T22:09:00Z |
| format | Article |
| id | doaj.art-37456ea804c343aba46cdc85d0695097 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T22:09:00Z |
| publishDate | 1991-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-37456ea804c343aba46cdc85d06950972022-12-21T21:30:47ZengElsevierJournal of Lipid Research0022-22751991-02-01322374379Analysis of two different tandem repetitive elements within the human apolipoprotein B gene.EH Ludwig0K Haubold1BJ McCarthy2Cardiovascular Research Institute, University of California, San Francisco 94140-0608.Cardiovascular Research Institute, University of California, San Francisco 94140-0608.Cardiovascular Research Institute, University of California, San Francisco 94140-0608.A large number of copies of the sequence (dTG-dAC)n, where n is between 10 and 60, exist in the human genome, and many are useful as polymorphic markers. One of these sequences occurs about 3 kilobases 5‘ of the human apolipoprotein (apo) B gene as seven distinguishable alleles containing from (TG)12 to (TG)18. This repeat is also present in the DNA of other primates. A second alternating purine-pyrimidine sequence with nine dinucleotide repeats and located in intron 4 is not polymorphic. Together with the apoB hypervariable repeat immediately 3‘ of the gene, the (TG)n sequence will provide a useful haplotype marker capable of distinguishing a large number of human apoB alleles, some of which may be associated with disease states.http://www.sciencedirect.com/science/article/pii/S002222752042098X |
| spellingShingle | EH Ludwig K Haubold BJ McCarthy Analysis of two different tandem repetitive elements within the human apolipoprotein B gene. Journal of Lipid Research |
| title | Analysis of two different tandem repetitive elements within the human apolipoprotein B gene. |
| title_full | Analysis of two different tandem repetitive elements within the human apolipoprotein B gene. |
| title_fullStr | Analysis of two different tandem repetitive elements within the human apolipoprotein B gene. |
| title_full_unstemmed | Analysis of two different tandem repetitive elements within the human apolipoprotein B gene. |
| title_short | Analysis of two different tandem repetitive elements within the human apolipoprotein B gene. |
| title_sort | analysis of two different tandem repetitive elements within the human apolipoprotein b gene |
| url | http://www.sciencedirect.com/science/article/pii/S002222752042098X |
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