Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes.

Interleukin-1β induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes.

The blood-brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglia...

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Bibliographic Details
Main Authors: Yue Wang, Shijie Jin, Yoshifumi Sonobe, Yi Cheng, Hiroshi Horiuchi, Bijay Parajuli, Jun Kawanokuchi, Tetsuya Mizuno, Hideyuki Takeuchi, Akio Suzumura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4196962?pdf=render

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