Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure

Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure

Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an oral drug would allow greater flexibility of administration and patient convenience; however, attempts have been fraught with high first-pass metabolism and potential intest...

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Bibliographic Details
Main Authors: Shannon Dow, Richard Burton, Richard Smith, Jingqi Bao, Enaksha Wickremsinhe, Everett Perkins
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Pharmaceutics
Subjects:
gemcitabine
prodrug
carboxylesterase
CES2
Online Access:http://www.mdpi.com/1999-4923/5/2/261

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