Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports
Abstract Background Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common side effect in patients treated with SSRIs and venlafaxine, while there is little information on SIADH in the treatment of duloxetine for pain. Case presentation The patients were an 83‐year‐old Japan...
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12279 |
| _version_ | 1811185665306525696 |
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| author | Aoi Sato Norio Yasui‐Furukori Yumiko Oda Misa Yang Yudai Suzuki Masataka Shinozaki Taro Shimizu Kazutaka Shimoda |
| author_facet | Aoi Sato Norio Yasui‐Furukori Yumiko Oda Misa Yang Yudai Suzuki Masataka Shinozaki Taro Shimizu Kazutaka Shimoda |
| author_sort | Aoi Sato |
| collection | DOAJ |
| description | Abstract Background Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common side effect in patients treated with SSRIs and venlafaxine, while there is little information on SIADH in the treatment of duloxetine for pain. Case presentation The patients were an 83‐year‐old Japanese male and a 71‐year‐old Japanese female. Several years earlier, they complained of pain. Accidentally, blood tests revealed hyponatremia of 110 mmol/L and 108 mmol/L 35 days and 40 days after initiating duloxetine 20 mg/day, respectively. The hyponatremia of both patients recovered after switching from duloxetine to mianserin. Conclusion We conclude that asymptomatic SIADH was induced by use of duloxetine. Psychiatrists should be aware of this syndrome. |
| first_indexed | 2024-04-11T13:34:06Z |
| format | Article |
| id | doaj.art-37467164f82146c5b1123faad13bea24 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-11T13:34:06Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-37467164f82146c5b1123faad13bea242022-12-22T04:21:39ZengWileyNeuropsychopharmacology Reports2574-173X2022-09-0142338739010.1002/npr2.12279Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reportsAoi Sato0Norio Yasui‐Furukori1Yumiko Oda2Misa Yang3Yudai Suzuki4Masataka Shinozaki5Taro Shimizu6Kazutaka Shimoda7Department of Psychiatry Dokkyo Medical University, School of Medicine Shimotsuga‐gun JapanDepartment of Psychiatry Dokkyo Medical University, School of Medicine Shimotsuga‐gun JapanDepartment of Psychiatry Dokkyo Medical University, School of Medicine Shimotsuga‐gun JapanDepartment of Diagnostic and Generalist Medicine Dokkyo Medical University Hospital, School of Medicine Shimotsuga‐gun JapanDepartment of Diagnostic and Generalist Medicine Dokkyo Medical University Hospital, School of Medicine Shimotsuga‐gun JapanDepartment of Psychiatry Dokkyo Medical University, School of Medicine Shimotsuga‐gun JapanDepartment of Diagnostic and Generalist Medicine Dokkyo Medical University Hospital, School of Medicine Shimotsuga‐gun JapanDepartment of Psychiatry Dokkyo Medical University, School of Medicine Shimotsuga‐gun JapanAbstract Background Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common side effect in patients treated with SSRIs and venlafaxine, while there is little information on SIADH in the treatment of duloxetine for pain. Case presentation The patients were an 83‐year‐old Japanese male and a 71‐year‐old Japanese female. Several years earlier, they complained of pain. Accidentally, blood tests revealed hyponatremia of 110 mmol/L and 108 mmol/L 35 days and 40 days after initiating duloxetine 20 mg/day, respectively. The hyponatremia of both patients recovered after switching from duloxetine to mianserin. Conclusion We conclude that asymptomatic SIADH was induced by use of duloxetine. Psychiatrists should be aware of this syndrome.https://doi.org/10.1002/npr2.12279duloxetineorthopedicspainSIADHSNRI |
| spellingShingle | Aoi Sato Norio Yasui‐Furukori Yumiko Oda Misa Yang Yudai Suzuki Masataka Shinozaki Taro Shimizu Kazutaka Shimoda Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports Neuropsychopharmacology Reports duloxetine orthopedics pain SIADH SNRI |
| title | Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports |
| title_full | Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports |
| title_fullStr | Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports |
| title_full_unstemmed | Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports |
| title_short | Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports |
| title_sort | asymptomatic syndrome of inappropriate secretion of antidiuretic hormone siadh following duloxetine treatment for pain with depression two case reports |
| topic | duloxetine orthopedics pain SIADH SNRI |
| url | https://doi.org/10.1002/npr2.12279 |
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