Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation
Allergic disorders commonly involve both chronic tissue inflammation and remodeling caused by immunological reactions to various antigens on tissue surfaces. Due to their anatomical location, vascular endothelial cells are the final responders to interact with various exogenous factors that come int...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015001744 |
| _version_ | 1818908034426994688 |
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| author | Tetsuo Shoda Kyoko Futamura Kanami Orihara Maiko Emi-Sugie Hirohisa Saito Kenji Matsumoto Akio Matsuda |
| author_facet | Tetsuo Shoda Kyoko Futamura Kanami Orihara Maiko Emi-Sugie Hirohisa Saito Kenji Matsumoto Akio Matsuda |
| author_sort | Tetsuo Shoda |
| collection | DOAJ |
| description | Allergic disorders commonly involve both chronic tissue inflammation and remodeling caused by immunological reactions to various antigens on tissue surfaces. Due to their anatomical location, vascular endothelial cells are the final responders to interact with various exogenous factors that come into contact with the epithelial surface, such as pathogen-associated molecular patterns (PAMPs) and antigens. Recent studies have shed light on the important roles of endothelial cells in the development and exacerbation of allergic disorders. For instance, endothelial cells have the greatest potential to produce several key molecules that are deeply involved in allergic inflammation, such as periostin and thymus and activation-regulated chemokine (TARC/CCL17). Additionally, endothelial cells were recently shown to be important functional targets for IL-33—an essential regulator of allergic inflammation. Notably, almost all endothelial cell responses and functions involved in allergic inflammation are not suppressed by corticosteroids. These corticosteroid-refractory endothelial cell responses and functions include TNF-α-associated angiogenesis, leukocyte adhesion, IL-33-mediated responses and periostin and TARC production. Therefore, these unique responses and functions of endothelial cells may be critically involved in the pathogenesis of various allergic disorders, especially their refractory processes. Here, we review recent studies, including ours, which have elucidated previously unknown pathophysiological roles of vascular endothelial cells in allergic inflammation and discuss the possibility of endothelium-targeted therapy for allergic disorders. |
| first_indexed | 2024-12-19T22:04:36Z |
| format | Article |
| id | doaj.art-37469853ffc04620a78210887752b758 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-19T22:04:36Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-37469853ffc04620a78210887752b7582022-12-21T20:04:04ZengElsevierAllergology International1323-89302016-01-01651212910.1016/j.alit.2015.08.001Recent advances in understanding the roles of vascular endothelial cells in allergic inflammationTetsuo ShodaKyoko FutamuraKanami OriharaMaiko Emi-SugieHirohisa SaitoKenji MatsumotoAkio MatsudaAllergic disorders commonly involve both chronic tissue inflammation and remodeling caused by immunological reactions to various antigens on tissue surfaces. Due to their anatomical location, vascular endothelial cells are the final responders to interact with various exogenous factors that come into contact with the epithelial surface, such as pathogen-associated molecular patterns (PAMPs) and antigens. Recent studies have shed light on the important roles of endothelial cells in the development and exacerbation of allergic disorders. For instance, endothelial cells have the greatest potential to produce several key molecules that are deeply involved in allergic inflammation, such as periostin and thymus and activation-regulated chemokine (TARC/CCL17). Additionally, endothelial cells were recently shown to be important functional targets for IL-33—an essential regulator of allergic inflammation. Notably, almost all endothelial cell responses and functions involved in allergic inflammation are not suppressed by corticosteroids. These corticosteroid-refractory endothelial cell responses and functions include TNF-α-associated angiogenesis, leukocyte adhesion, IL-33-mediated responses and periostin and TARC production. Therefore, these unique responses and functions of endothelial cells may be critically involved in the pathogenesis of various allergic disorders, especially their refractory processes. Here, we review recent studies, including ours, which have elucidated previously unknown pathophysiological roles of vascular endothelial cells in allergic inflammation and discuss the possibility of endothelium-targeted therapy for allergic disorders.http://www.sciencedirect.com/science/article/pii/S1323893015001744AllergyAngiogenesisCorticosteroidEndothelial cellsInflammation |
| spellingShingle | Tetsuo Shoda Kyoko Futamura Kanami Orihara Maiko Emi-Sugie Hirohisa Saito Kenji Matsumoto Akio Matsuda Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation Allergology International Allergy Angiogenesis Corticosteroid Endothelial cells Inflammation |
| title | Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation |
| title_full | Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation |
| title_fullStr | Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation |
| title_full_unstemmed | Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation |
| title_short | Recent advances in understanding the roles of vascular endothelial cells in allergic inflammation |
| title_sort | recent advances in understanding the roles of vascular endothelial cells in allergic inflammation |
| topic | Allergy Angiogenesis Corticosteroid Endothelial cells Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015001744 |
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