Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension
Hypertension can cause structural and functional abnormalities in the cardiovascular system, which can be attributed to both hemodynamic and nonhemodynamic factors. These alterations are linked with metabolic changes and are induced by pathological stressors. Sirtuins are enzymes that act as stress...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/5/686 |
| _version_ | 1797600986088341504 |
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| author | Jing Gao Weili Shen |
| author_facet | Jing Gao Weili Shen |
| author_sort | Jing Gao |
| collection | DOAJ |
| description | Hypertension can cause structural and functional abnormalities in the cardiovascular system, which can be attributed to both hemodynamic and nonhemodynamic factors. These alterations are linked with metabolic changes and are induced by pathological stressors. Sirtuins are enzymes that act as stress sensors and regulate metabolic adaptation by deacetylating proteins. Among them, mitochondrial SIRT3 performs a crucial role in maintaining metabolic homeostasis. Evidence from experimental and clinical studies has shown that hypertension-induced decreases in SIRT3 activity can lead to cellular metabolism reprogramming and, subsequently, increased susceptibility to endothelial dysfunction, myocardial hypertrophy, myocardial fibrosis, and heart failure. This review presents recent research advances in SIRT3-mediated metabolic adaptation in hypertensive cardiovascular remodeling. |
| first_indexed | 2024-03-11T03:55:30Z |
| format | Article |
| id | doaj.art-3746de0a7c4b46969124c351223d95ca |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T03:55:30Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-3746de0a7c4b46969124c351223d95ca2023-11-18T00:32:58ZengMDPI AGBiology2079-77372023-05-0112568610.3390/biology12050686Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with HypertensionJing Gao0Weili Shen1Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaHypertension can cause structural and functional abnormalities in the cardiovascular system, which can be attributed to both hemodynamic and nonhemodynamic factors. These alterations are linked with metabolic changes and are induced by pathological stressors. Sirtuins are enzymes that act as stress sensors and regulate metabolic adaptation by deacetylating proteins. Among them, mitochondrial SIRT3 performs a crucial role in maintaining metabolic homeostasis. Evidence from experimental and clinical studies has shown that hypertension-induced decreases in SIRT3 activity can lead to cellular metabolism reprogramming and, subsequently, increased susceptibility to endothelial dysfunction, myocardial hypertrophy, myocardial fibrosis, and heart failure. This review presents recent research advances in SIRT3-mediated metabolic adaptation in hypertensive cardiovascular remodeling.https://www.mdpi.com/2079-7737/12/5/686SIRT3metabolic reprogrammingcardiovascular remodelinghypertension |
| spellingShingle | Jing Gao Weili Shen Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension Biology SIRT3 metabolic reprogramming cardiovascular remodeling hypertension |
| title | Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension |
| title_full | Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension |
| title_fullStr | Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension |
| title_full_unstemmed | Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension |
| title_short | Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension |
| title_sort | sirtuin 3 mediated cellular metabolism links cardiovascular remodeling with hypertension |
| topic | SIRT3 metabolic reprogramming cardiovascular remodeling hypertension |
| url | https://www.mdpi.com/2079-7737/12/5/686 |
| work_keys_str_mv | AT jinggao sirtuin3mediatedcellularmetabolismlinkscardiovascularremodelingwithhypertension AT weilishen sirtuin3mediatedcellularmetabolismlinkscardiovascularremodelingwithhypertension |