Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease
The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested. AD is one of the age-related dementias, and is characterized by cognitive impairment with decreased memory function. D...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/3/647 |
| _version_ | 1797610639863054336 |
|---|---|
| author | Tadahiro Numakawa Ryutaro Kajihara |
| author_facet | Tadahiro Numakawa Ryutaro Kajihara |
| author_sort | Tadahiro Numakawa |
| collection | DOAJ |
| description | The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested. AD is one of the age-related dementias, and is characterized by cognitive impairment with decreased memory function. Developing evidence demonstrates that decreased cell survival, synaptic dysfunction, and reduced neurogenesis are involved in the pathogenesis of AD. On the other hand, it is well known that neurotrophic factors, especially brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB, have multiple roles in the central nervous system (CNS), including neuronal maintenance, synaptic plasticity, and neurogenesis, which are closely linked to learning and memory function. Thus, many investigations regarding therapeutic approaches to AD, and/or the screening of novel drug candidates for its treatment, focus on upregulation of the BDNF/TrkB system. Furthermore, current studies also demonstrate that GDNF, IGF1, and bFGF, which play roles in neuroprotection, are associated with AD. In this review, we introduce data demonstrating close relationships between the pathogenesis of AD, neurotrophic factors, and drug candidates, including natural compounds that upregulate the BDNF-mediated neurotrophic system. |
| first_indexed | 2024-03-11T06:17:03Z |
| format | Article |
| id | doaj.art-37470f306aa4468f84517b10bbca30d5 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:03Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-37470f306aa4468f84517b10bbca30d52023-11-17T12:10:25ZengMDPI AGLife2075-17292023-02-0113364710.3390/life13030647Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s DiseaseTadahiro Numakawa0Ryutaro Kajihara1Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, JapanDepartment of Biomedical Laboratory Sciences, Faculty of Life Science, Kumamoto University, Kumamoto 862-0976, JapanThe involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested. AD is one of the age-related dementias, and is characterized by cognitive impairment with decreased memory function. Developing evidence demonstrates that decreased cell survival, synaptic dysfunction, and reduced neurogenesis are involved in the pathogenesis of AD. On the other hand, it is well known that neurotrophic factors, especially brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB, have multiple roles in the central nervous system (CNS), including neuronal maintenance, synaptic plasticity, and neurogenesis, which are closely linked to learning and memory function. Thus, many investigations regarding therapeutic approaches to AD, and/or the screening of novel drug candidates for its treatment, focus on upregulation of the BDNF/TrkB system. Furthermore, current studies also demonstrate that GDNF, IGF1, and bFGF, which play roles in neuroprotection, are associated with AD. In this review, we introduce data demonstrating close relationships between the pathogenesis of AD, neurotrophic factors, and drug candidates, including natural compounds that upregulate the BDNF-mediated neurotrophic system.https://www.mdpi.com/2075-1729/13/3/647BDNFTrkBp75NTRAlzheimer’s diseaseGDNFIGF-I |
| spellingShingle | Tadahiro Numakawa Ryutaro Kajihara Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease Life BDNF TrkB p75NTR Alzheimer’s disease GDNF IGF-I |
| title | Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease |
| title_full | Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease |
| title_fullStr | Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease |
| title_full_unstemmed | Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease |
| title_short | Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease |
| title_sort | neurotrophins and other growth factors in the pathogenesis of alzheimer s disease |
| topic | BDNF TrkB p75NTR Alzheimer’s disease GDNF IGF-I |
| url | https://www.mdpi.com/2075-1729/13/3/647 |
| work_keys_str_mv | AT tadahironumakawa neurotrophinsandothergrowthfactorsinthepathogenesisofalzheimersdisease AT ryutarokajihara neurotrophinsandothergrowthfactorsinthepathogenesisofalzheimersdisease |