MMP-7 is a non-invasive biomarker of chronic liver diseases
Introduction and Objectives: This study aimed to evaluate serum concentrations of MMP-7 in different liver etiologies and according to fibrosis stage. Materials and methods: A cross-sectional and multicenter study was carried out, including subjects with alcoholism (WHO criteria), without (OH) and w...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268122002113 |
| _version_ | 1811214075657453568 |
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| author | D Montes de Oca-Angeles M Lemus-Peña A Hernandez-Barragan M Hernández-Santillán M Martinez-Castillo D Santana-Vargas Z Medina-Avila A Torre-Delgadillo JL Pérez-Hernández F Higuera-De la Tijera P Cordero-Pérez L Muñoz-Espinosa D Kershenobich G Gutiérrez-Reyes |
| author_facet | D Montes de Oca-Angeles M Lemus-Peña A Hernandez-Barragan M Hernández-Santillán M Martinez-Castillo D Santana-Vargas Z Medina-Avila A Torre-Delgadillo JL Pérez-Hernández F Higuera-De la Tijera P Cordero-Pérez L Muñoz-Espinosa D Kershenobich G Gutiérrez-Reyes |
| author_sort | D Montes de Oca-Angeles |
| collection | DOAJ |
| description | Introduction and Objectives: This study aimed to evaluate serum concentrations of MMP-7 in different liver etiologies and according to fibrosis stage. Materials and methods: A cross-sectional and multicenter study was carried out, including subjects with alcoholism (WHO criteria), without (OH) and with liver injury (cirrhosis, CiOH); diagnosed by clinical, biochemical data, non-alcoholic fatty liver (NAFLD) and chronic Hepatitis C (CHC). Transitional elastography (Fibroscan) was performed in NAFLD and CHC, considering mild fibrosis (MF: F0, F1, F2) and advanced fibrosis (AF: F3, F4). As controls, subjects without alcohol consumption (CT) were recruited. For the quantification of MMP-7, Multiplex-MERCK© was used. Statistical analysis was performed using SPSS V.22 using Mann Whitney U, p<0.05. Results: It was included 99 subjects (OH); 45 (CiOH); 48 (CHC, FL); 54 (CHC, FA); 27 (NAFLD, FL); 36 (NAFLD, AF) and 131 CT. MMP-7 was found to be elevated in CHC (FL and FA), vs. CT; and decreased in OH, CiOH, NAFLD (FL and FA) vs. CT, plus there are significant differences between all etiologies, p<0.001. Discussion: MMP-7 is a matrilysin that degrades extracellular matrix products (proteoglycans); it increases significantly in subjects with CHC compared to CT, while in other pathologies with stages, even in advanced fibrosis, the levels are decreased compared to CT. Conclusion: The increased MMP-7 in serum of chronic Hepatitis C and decreased in alcoholism and non-alcoholic fatty liver patients suggests that, according to the etiology, the levels can be useful to make a differential diagnosis. It is a potential non-invasive biomarker. Funding: This work was partially financed by CONACyT SALUD-2016-272579 and PAPIIT- UNAM TA200515. Declaration of interest: The authors declare no potential conflicts of interest. |
| first_indexed | 2024-04-12T05:56:56Z |
| format | Article |
| id | doaj.art-3748ac3293af4c1a9fee1fe241754208 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-04-12T05:56:56Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-3748ac3293af4c1a9fee1fe2417542082022-12-22T03:45:08ZengElsevierAnnals of Hepatology1665-26812022-12-0127100869MMP-7 is a non-invasive biomarker of chronic liver diseasesD Montes de Oca-Angeles0M Lemus-Peña1A Hernandez-Barragan2M Hernández-Santillán3M Martinez-Castillo4D Santana-Vargas5Z Medina-Avila6A Torre-Delgadillo7JL Pérez-Hernández8F Higuera-De la Tijera9P Cordero-Pérez10L Muñoz-Espinosa11D Kershenobich12G Gutiérrez-Reyes13Liver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoLiver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoLiver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoLiver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoLiver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoDepartment of Gastroenterology. General Hospital of Mexico “Dr. Eduardo Liceaga.” México City. MéxicoLiver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoDepartment of Gastroenterology. General Hospital of Mexico “Dr. Eduardo Liceaga.” México City. MéxicoDepartment of Gastroenterology. General Hospital of Mexico “Dr. Eduardo Liceaga.” México City. MéxicoDepartment of Gastroenterology. General Hospital of Mexico “Dr. Eduardo Liceaga.” México City. MéxicoUniversitary Hospital “Dr. José Eluterio González”. School of Medicine. UANL. Nuevo Leon. México City. MéxicoUniversitary Hospital “Dr. José Eluterio González”. School of Medicine. UANL. Nuevo Leon. México City. MéxicoNational Institute of Medical Sciences and Nutrition “Salvador Zubirán.” Mexico City. MexicoLiver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. MexicoIntroduction and Objectives: This study aimed to evaluate serum concentrations of MMP-7 in different liver etiologies and according to fibrosis stage. Materials and methods: A cross-sectional and multicenter study was carried out, including subjects with alcoholism (WHO criteria), without (OH) and with liver injury (cirrhosis, CiOH); diagnosed by clinical, biochemical data, non-alcoholic fatty liver (NAFLD) and chronic Hepatitis C (CHC). Transitional elastography (Fibroscan) was performed in NAFLD and CHC, considering mild fibrosis (MF: F0, F1, F2) and advanced fibrosis (AF: F3, F4). As controls, subjects without alcohol consumption (CT) were recruited. For the quantification of MMP-7, Multiplex-MERCK© was used. Statistical analysis was performed using SPSS V.22 using Mann Whitney U, p<0.05. Results: It was included 99 subjects (OH); 45 (CiOH); 48 (CHC, FL); 54 (CHC, FA); 27 (NAFLD, FL); 36 (NAFLD, AF) and 131 CT. MMP-7 was found to be elevated in CHC (FL and FA), vs. CT; and decreased in OH, CiOH, NAFLD (FL and FA) vs. CT, plus there are significant differences between all etiologies, p<0.001. Discussion: MMP-7 is a matrilysin that degrades extracellular matrix products (proteoglycans); it increases significantly in subjects with CHC compared to CT, while in other pathologies with stages, even in advanced fibrosis, the levels are decreased compared to CT. Conclusion: The increased MMP-7 in serum of chronic Hepatitis C and decreased in alcoholism and non-alcoholic fatty liver patients suggests that, according to the etiology, the levels can be useful to make a differential diagnosis. It is a potential non-invasive biomarker. Funding: This work was partially financed by CONACyT SALUD-2016-272579 and PAPIIT- UNAM TA200515. Declaration of interest: The authors declare no potential conflicts of interest.http://www.sciencedirect.com/science/article/pii/S1665268122002113 |
| spellingShingle | D Montes de Oca-Angeles M Lemus-Peña A Hernandez-Barragan M Hernández-Santillán M Martinez-Castillo D Santana-Vargas Z Medina-Avila A Torre-Delgadillo JL Pérez-Hernández F Higuera-De la Tijera P Cordero-Pérez L Muñoz-Espinosa D Kershenobich G Gutiérrez-Reyes MMP-7 is a non-invasive biomarker of chronic liver diseases Annals of Hepatology |
| title | MMP-7 is a non-invasive biomarker of chronic liver diseases |
| title_full | MMP-7 is a non-invasive biomarker of chronic liver diseases |
| title_fullStr | MMP-7 is a non-invasive biomarker of chronic liver diseases |
| title_full_unstemmed | MMP-7 is a non-invasive biomarker of chronic liver diseases |
| title_short | MMP-7 is a non-invasive biomarker of chronic liver diseases |
| title_sort | mmp 7 is a non invasive biomarker of chronic liver diseases |
| url | http://www.sciencedirect.com/science/article/pii/S1665268122002113 |
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