Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study
Objectives: Osteoprotegerin (OPG) has an important role in bone remodeling, and it has been proposed that the OPG gene might be a candidate gene for osteoporosis predisposition. Several studies have already assessed the connection between OPG gene polymorphism and bone mineral density (BMD). In th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-03-01
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| Series: | Rheumatology |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Osteoporosis-and-polymorphisms-of-osteoprotegerin-gene-in-postmenopausal-women-a-pilot-study,18,27168,1,1.html |
| _version_ | 1818062986268377088 |
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| author | Selma Cvijetic Simeon Grazio Pasezada Kosovic Melita Uremovic Tomislav Nemcic Jasminka Bobic |
| author_facet | Selma Cvijetic Simeon Grazio Pasezada Kosovic Melita Uremovic Tomislav Nemcic Jasminka Bobic |
| author_sort | Selma Cvijetic |
| collection | DOAJ |
| description | Objectives: Osteoprotegerin (OPG) has an important role in bone remodeling, and it has been proposed that the OPG gene might be a candidate gene for osteoporosis predisposition. Several studies have already assessed the connection between OPG gene polymorphism and bone mineral density (BMD). In this study we wanted to analyze the association of two polymorphisms in the OPG gene with BMD and bone turnover markers in women with and without osteoporosis.
Material and methods: In 22 postmenopausal women with osteoporosis (aged 65.6 ±12.6) and 59 women without osteoporosis (aged 60.8 ±8.7) we analyzed the association of two polymorphisms in the OPG gene with BMD, measured by dual energy absorptiometry and with bone turnover markers (crosslaps and osteoprotegerin). A163G, G209A, T245G and G1181C polymorphisms were determined.
Results: No significant differences in age, anthropometry, number of fractures, osteocalcin and cross-laps were found between women with and without osteoporosis. Women with osteoporosis were significantly longer in postmenopause. Significantly more women with osteoporosis had AG polymorphism (p = 0.038) compared to women without osteoporosis, while no significant difference was found in prevalence of TT and GG polymorphism between patients with and without osteoporosis. No relationship was found between investigated polymorphism and bone turnover markers. A significant negative correlation between total hip BMD and crosslaps (p = 0.046) as well as between total hip T score and crosslaps (p = 0.044) was found in women without osteoporosis
Conclusions : Postmenopausal women with osteoporosis had AG polymorphism more frequently than women without osteoporosis. Our results indicate that A163G polymorphism could have an impact on higher bone loss in postmenopausal women. |
| first_indexed | 2024-12-10T14:12:55Z |
| format | Article |
| id | doaj.art-374c8a29692f4ed8977d9049234b0759 |
| institution | Directory Open Access Journal |
| issn | 0034-6233 2084-9834 |
| language | English |
| last_indexed | 2024-12-10T14:12:55Z |
| publishDate | 2016-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj.art-374c8a29692f4ed8977d9049234b07592022-12-22T01:45:26ZengTermedia Publishing HouseRheumatology0034-62332084-98342016-03-01541101310.5114/reum.2016.5875527168Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot studySelma CvijeticSimeon GrazioPasezada KosovicMelita UremovicTomislav NemcicJasminka BobicObjectives: Osteoprotegerin (OPG) has an important role in bone remodeling, and it has been proposed that the OPG gene might be a candidate gene for osteoporosis predisposition. Several studies have already assessed the connection between OPG gene polymorphism and bone mineral density (BMD). In this study we wanted to analyze the association of two polymorphisms in the OPG gene with BMD and bone turnover markers in women with and without osteoporosis. Material and methods: In 22 postmenopausal women with osteoporosis (aged 65.6 ±12.6) and 59 women without osteoporosis (aged 60.8 ±8.7) we analyzed the association of two polymorphisms in the OPG gene with BMD, measured by dual energy absorptiometry and with bone turnover markers (crosslaps and osteoprotegerin). A163G, G209A, T245G and G1181C polymorphisms were determined. Results: No significant differences in age, anthropometry, number of fractures, osteocalcin and cross-laps were found between women with and without osteoporosis. Women with osteoporosis were significantly longer in postmenopause. Significantly more women with osteoporosis had AG polymorphism (p = 0.038) compared to women without osteoporosis, while no significant difference was found in prevalence of TT and GG polymorphism between patients with and without osteoporosis. No relationship was found between investigated polymorphism and bone turnover markers. A significant negative correlation between total hip BMD and crosslaps (p = 0.046) as well as between total hip T score and crosslaps (p = 0.044) was found in women without osteoporosis Conclusions : Postmenopausal women with osteoporosis had AG polymorphism more frequently than women without osteoporosis. Our results indicate that A163G polymorphism could have an impact on higher bone loss in postmenopausal women.http://www.termedia.pl/Osteoporosis-and-polymorphisms-of-osteoprotegerin-gene-in-postmenopausal-women-a-pilot-study,18,27168,1,1.htmlosteoprotegerin osteoporosis gene polymorphism postmenopause osteocalcin crosslaps |
| spellingShingle | Selma Cvijetic Simeon Grazio Pasezada Kosovic Melita Uremovic Tomislav Nemcic Jasminka Bobic Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study Rheumatology osteoprotegerin osteoporosis gene polymorphism postmenopause osteocalcin crosslaps |
| title | Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study |
| title_full | Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study |
| title_fullStr | Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study |
| title_full_unstemmed | Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study |
| title_short | Osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women – a pilot study |
| title_sort | osteoporosis and polymorphisms of osteoprotegerin gene in postmenopausal women a pilot study |
| topic | osteoprotegerin osteoporosis gene polymorphism postmenopause osteocalcin crosslaps |
| url | http://www.termedia.pl/Osteoporosis-and-polymorphisms-of-osteoprotegerin-gene-in-postmenopausal-women-a-pilot-study,18,27168,1,1.html |
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