Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients
PURPOSETo analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttrium- 90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.METHODSInterleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-09-01
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| Series: | Diagnostic and Interventional Radiology |
| Subjects: | |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/short-term-changes-of-angiogenesis-factors-after-t/57976
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| _version_ | 1797691415796383744 |
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| author | Hüseyin Tuğsan Ballı Kairgeldy Aikimbaev İsa Güney Burak Ferhat Can Pişkin |
| author_facet | Hüseyin Tuğsan Ballı Kairgeldy Aikimbaev İsa Güney Burak Ferhat Can Pişkin |
| author_sort | Hüseyin Tuğsan Ballı |
| collection | DOAJ |
| description | PURPOSETo analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttrium- 90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.METHODSInterleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 patients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.RESULTSIn the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treatment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 (P = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders (P = 0.036).CONCLUSIONShort-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recognition of non-responders. |
| first_indexed | 2024-03-12T02:12:59Z |
| format | Article |
| id | doaj.art-374c99b50c194be597ead141c0fbf785 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:12:59Z |
| publishDate | 2023-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-374c99b50c194be597ead141c0fbf7852023-09-06T11:33:40ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122023-09-0129570470910.4274/dir.2021.21125513049054Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patientsHüseyin Tuğsan Ballı0Kairgeldy Aikimbaev1İsa Güney Burak2Ferhat Can Pişkin3 Department of Radiology, Çukurova University Faculty of Medicine, Balçalı Hospital Health Application and Research Center, Adana, Turkey Department of Radiology, Çukurova University Faculty of Medicine, Balçalı Hospital Health Application and Research Center, Adana, Turkey Department of Nuclear Medicine, Çukurova University Faculty of Medicine, Balçalı Hospital Health Application and Research Center, Adana, Turkey Department of Radiology, Çukurova University Faculty of Medicine, Balçalı Hospital Health Application and Research Center, Adana, Turkey PURPOSETo analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttrium- 90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.METHODSInterleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 patients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.RESULTSIn the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treatment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 (P = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders (P = 0.036).CONCLUSIONShort-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recognition of non-responders. http://www.dirjournal.org/archives/archive-detail/article-preview/short-term-changes-of-angiogenesis-factors-after-t/57976 angiogenesishepatocellular carcinomaresin microspherestransarterial radioembolizationy-90 |
| spellingShingle | Hüseyin Tuğsan Ballı Kairgeldy Aikimbaev İsa Güney Burak Ferhat Can Pişkin Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients Diagnostic and Interventional Radiology angiogenesis hepatocellular carcinoma resin microspheres transarterial radioembolization y-90 |
| title | Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients |
| title_full | Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients |
| title_fullStr | Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients |
| title_full_unstemmed | Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients |
| title_short | Short-term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients |
| title_sort | short term changes of angiogenesis factors after transarterial radioembolization in hepatocellular carcinoma patients |
| topic | angiogenesis hepatocellular carcinoma resin microspheres transarterial radioembolization y-90 |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/short-term-changes-of-angiogenesis-factors-after-t/57976
|
| work_keys_str_mv | AT huseyintugsanballı shorttermchangesofangiogenesisfactorsaftertransarterialradioembolizationinhepatocellularcarcinomapatients AT kairgeldyaikimbaev shorttermchangesofangiogenesisfactorsaftertransarterialradioembolizationinhepatocellularcarcinomapatients AT isaguneyburak shorttermchangesofangiogenesisfactorsaftertransarterialradioembolizationinhepatocellularcarcinomapatients AT ferhatcanpiskin shorttermchangesofangiogenesisfactorsaftertransarterialradioembolizationinhepatocellularcarcinomapatients |