Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances
Ionising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/11/1763 |
| _version_ | 1797511415967252480 |
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| author | Artem M. Ermakov Kristina A. Kamenskikh Olga N. Ermakova Artem S. Blagodatsky Anton L. Popov Vladimir K. Ivanov |
| author_facet | Artem M. Ermakov Kristina A. Kamenskikh Olga N. Ermakova Artem S. Blagodatsky Anton L. Popov Vladimir K. Ivanov |
| author_sort | Artem M. Ermakov |
| collection | DOAJ |
| description | Ionising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi treatments, the rapid development of clear phenotypes, and sensitivity to ionising radiation, combined with new genomic technologies, make planarians an outstanding tool for the discovery of potential radioprotective agents. In this work, using the well-known antioxidant N-acetylcysteine, planarians are, for the first time, shown to be an excellent model system for the fast and effective screening of novel radioprotective and radio-sensitising substances. In addition, a panel of measurable parameters that can be used for the study of radioprotective effects on this model is suggested. |
| first_indexed | 2024-03-10T05:44:58Z |
| format | Article |
| id | doaj.art-374cd3698525474ea4aa5c4390548866 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:44:58Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-374cd3698525474ea4aa5c43905488662023-11-22T22:13:20ZengMDPI AGAntioxidants2076-39212021-11-011011176310.3390/antiox10111763Planarians as an In Vivo Experimental Model for the Study of New Radioprotective SubstancesArtem M. Ermakov0Kristina A. Kamenskikh1Olga N. Ermakova2Artem S. Blagodatsky3Anton L. Popov4Vladimir K. Ivanov5Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, RussiaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, RussiaIonising radiation causes the death of the most actively dividing cells, thus leading to depletion of the stem cell pool. Planarians are invertebrate flatworms that are unique in that their stem cells, called neoblasts, constantly replace old, damaged, or dying cells. Amenability to efficient RNAi treatments, the rapid development of clear phenotypes, and sensitivity to ionising radiation, combined with new genomic technologies, make planarians an outstanding tool for the discovery of potential radioprotective agents. In this work, using the well-known antioxidant N-acetylcysteine, planarians are, for the first time, shown to be an excellent model system for the fast and effective screening of novel radioprotective and radio-sensitising substances. In addition, a panel of measurable parameters that can be used for the study of radioprotective effects on this model is suggested.https://www.mdpi.com/2076-3921/10/11/1763planariansmodel animalirradiationregenerationradioprotection |
| spellingShingle | Artem M. Ermakov Kristina A. Kamenskikh Olga N. Ermakova Artem S. Blagodatsky Anton L. Popov Vladimir K. Ivanov Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances Antioxidants planarians model animal irradiation regeneration radioprotection |
| title | Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances |
| title_full | Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances |
| title_fullStr | Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances |
| title_full_unstemmed | Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances |
| title_short | Planarians as an In Vivo Experimental Model for the Study of New Radioprotective Substances |
| title_sort | planarians as an in vivo experimental model for the study of new radioprotective substances |
| topic | planarians model animal irradiation regeneration radioprotection |
| url | https://www.mdpi.com/2076-3921/10/11/1763 |
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