Novelty detection in an auditory oddball task on freely moving rats
Abstract The relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05403-y |
| _version_ | 1797557196348719104 |
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| author | Laura Quintela-Vega Camilo J. Morado-Díaz Gonzalo Terreros Jazmín S. Sánchez David Pérez-González Manuel S. Malmierca |
| author_facet | Laura Quintela-Vega Camilo J. Morado-Díaz Gonzalo Terreros Jazmín S. Sánchez David Pérez-González Manuel S. Malmierca |
| author_sort | Laura Quintela-Vega |
| collection | DOAJ |
| description | Abstract The relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repeating stimuli and different variations of the classic oddball paradigm, can detect deviant tones, and this discriminability resembles the properties that are typical of neuronal adaptation described in previous studies. Moreover, the auditory brainstem response (ABR) latency decreases after training, a finding consistent with the notion that animals develop a type of plasticity to auditory stimuli. Our study suggests the existence of a form of long-term memory that may modulate the level of neuronal adaptation according to its behavioural relevance, and sets the ground for future experiments that will help to disentangle the functional mechanisms that govern behavioural habituation and its relation to neuronal adaptation. |
| first_indexed | 2024-03-10T17:13:56Z |
| format | Article |
| id | doaj.art-374f3bdd1daa442fabee64a23fb924a7 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-10T17:13:56Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-374f3bdd1daa442fabee64a23fb924a72023-11-20T10:33:25ZengNature PortfolioCommunications Biology2399-36422023-10-016111510.1038/s42003-023-05403-yNovelty detection in an auditory oddball task on freely moving ratsLaura Quintela-Vega0Camilo J. Morado-Díaz1Gonzalo Terreros2Jazmín S. Sánchez3David Pérez-González4Manuel S. Malmierca5Cognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y LeónCognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y LeónCognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y LeónCognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y LeónCognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y LeónCognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y LeónAbstract The relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repeating stimuli and different variations of the classic oddball paradigm, can detect deviant tones, and this discriminability resembles the properties that are typical of neuronal adaptation described in previous studies. Moreover, the auditory brainstem response (ABR) latency decreases after training, a finding consistent with the notion that animals develop a type of plasticity to auditory stimuli. Our study suggests the existence of a form of long-term memory that may modulate the level of neuronal adaptation according to its behavioural relevance, and sets the ground for future experiments that will help to disentangle the functional mechanisms that govern behavioural habituation and its relation to neuronal adaptation.https://doi.org/10.1038/s42003-023-05403-y |
| spellingShingle | Laura Quintela-Vega Camilo J. Morado-Díaz Gonzalo Terreros Jazmín S. Sánchez David Pérez-González Manuel S. Malmierca Novelty detection in an auditory oddball task on freely moving rats Communications Biology |
| title | Novelty detection in an auditory oddball task on freely moving rats |
| title_full | Novelty detection in an auditory oddball task on freely moving rats |
| title_fullStr | Novelty detection in an auditory oddball task on freely moving rats |
| title_full_unstemmed | Novelty detection in an auditory oddball task on freely moving rats |
| title_short | Novelty detection in an auditory oddball task on freely moving rats |
| title_sort | novelty detection in an auditory oddball task on freely moving rats |
| url | https://doi.org/10.1038/s42003-023-05403-y |
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