Why prevent, diagnose and treat congenital toxoplasmosis?
Evidence that prevention, diagnosis and treatment of toxoplasmosis is beneficial developed as follows: anti-parasitic agents abrogate Toxoplasma gondiitachyzoite growth, preventing destruction of infected, cultured, mammalian cells and cure active infections in experimental animals, including primat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2009-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000200029 |
| _version_ | 1827833144508678144 |
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| author | Rima McLeod Francois Kieffer Mari Sautter Tiffany Hosten Herve Pelloux |
| author_facet | Rima McLeod Francois Kieffer Mari Sautter Tiffany Hosten Herve Pelloux |
| author_sort | Rima McLeod |
| collection | DOAJ |
| description | Evidence that prevention, diagnosis and treatment of toxoplasmosis is beneficial developed as follows: anti-parasitic agents abrogate Toxoplasma gondiitachyzoite growth, preventing destruction of infected, cultured, mammalian cells and cure active infections in experimental animals, including primates. They treat active infections in persons who are immune-compromised, limit destruction of retina by replicating parasites and thereby treat ocular toxoplasmosis and treat active infection in the fetus and infant. Outcomes of untreated congenital toxoplasmosis include adverse ocular and neurologic sequelae described in different countries and decades. Better outcomes are associated with treatment of infected infants throughout their first year of life. Shorter intervals between diagnosis and treatment in utero improve outcomes. A French approach for diagnosis and treatment of congenital toxoplasmosis in the fetus and infant can prevent toxoplasmosis and limit adverse sequelae. In addition, new data demonstrate that this French approach results in favorable outcomes with some early gestation infections. A standardized approach to diagnosis and treatment during gestation has not yet been applied generally in the USA. Nonetheless, a small, similar experience confirms that this French approach is feasible, safe, and results in favorable outcomes in the National Collaborative Chicago-based Congenital Toxoplasmosis Study cohort. Prompt diagnosis, prevention and treatment reduce adverse sequelae of congenital toxoplasmosis. |
| first_indexed | 2024-03-12T05:25:34Z |
| format | Article |
| id | doaj.art-375026510c014fa0b44dbc3cf0c99144 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:25:34Z |
| publishDate | 2009-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-375026510c014fa0b44dbc3cf0c991442023-09-03T07:24:30ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-03-01104232034410.1590/S0074-02762009000200029Why prevent, diagnose and treat congenital toxoplasmosis?Rima McLeodFrancois KiefferMari SautterTiffany HostenHerve PellouxEvidence that prevention, diagnosis and treatment of toxoplasmosis is beneficial developed as follows: anti-parasitic agents abrogate Toxoplasma gondiitachyzoite growth, preventing destruction of infected, cultured, mammalian cells and cure active infections in experimental animals, including primates. They treat active infections in persons who are immune-compromised, limit destruction of retina by replicating parasites and thereby treat ocular toxoplasmosis and treat active infection in the fetus and infant. Outcomes of untreated congenital toxoplasmosis include adverse ocular and neurologic sequelae described in different countries and decades. Better outcomes are associated with treatment of infected infants throughout their first year of life. Shorter intervals between diagnosis and treatment in utero improve outcomes. A French approach for diagnosis and treatment of congenital toxoplasmosis in the fetus and infant can prevent toxoplasmosis and limit adverse sequelae. In addition, new data demonstrate that this French approach results in favorable outcomes with some early gestation infections. A standardized approach to diagnosis and treatment during gestation has not yet been applied generally in the USA. Nonetheless, a small, similar experience confirms that this French approach is feasible, safe, and results in favorable outcomes in the National Collaborative Chicago-based Congenital Toxoplasmosis Study cohort. Prompt diagnosis, prevention and treatment reduce adverse sequelae of congenital toxoplasmosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000200029congenital toxoplasmosispreventiontreatment |
| spellingShingle | Rima McLeod Francois Kieffer Mari Sautter Tiffany Hosten Herve Pelloux Why prevent, diagnose and treat congenital toxoplasmosis? Memorias do Instituto Oswaldo Cruz congenital toxoplasmosis prevention treatment |
| title | Why prevent, diagnose and treat congenital toxoplasmosis? |
| title_full | Why prevent, diagnose and treat congenital toxoplasmosis? |
| title_fullStr | Why prevent, diagnose and treat congenital toxoplasmosis? |
| title_full_unstemmed | Why prevent, diagnose and treat congenital toxoplasmosis? |
| title_short | Why prevent, diagnose and treat congenital toxoplasmosis? |
| title_sort | why prevent diagnose and treat congenital toxoplasmosis |
| topic | congenital toxoplasmosis prevention treatment |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000200029 |
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