MHC matching improves engraftment of iPSC-derived neurons in non-human primates
Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00926-5 |
| _version_ | 1818682990353448960 |
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| author | Asuka Morizane Tetsuhiro Kikuchi Takuya Hayashi Hiroshi Mizuma Sayuki Takara Hisashi Doi Aya Mawatari Matthew F. Glasser Takashi Shiina Hirohito Ishigaki Yasushi Itoh Keisuke Okita Emi Yamasaki Daisuke Doi Hirotaka Onoe Kazumasa Ogasawara Shinya Yamanaka Jun Takahashi |
| author_facet | Asuka Morizane Tetsuhiro Kikuchi Takuya Hayashi Hiroshi Mizuma Sayuki Takara Hisashi Doi Aya Mawatari Matthew F. Glasser Takashi Shiina Hirohito Ishigaki Yasushi Itoh Keisuke Okita Emi Yamasaki Daisuke Doi Hirotaka Onoe Kazumasa Ogasawara Shinya Yamanaka Jun Takahashi |
| author_sort | Asuka Morizane |
| collection | DOAJ |
| description | Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons. |
| first_indexed | 2024-12-17T10:27:37Z |
| format | Article |
| id | doaj.art-37518cb36fd0402692f5bdd69bd784da |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:27:37Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-37518cb36fd0402692f5bdd69bd784da2022-12-21T21:52:36ZengNature PortfolioNature Communications2041-17232017-08-018111210.1038/s41467-017-00926-5MHC matching improves engraftment of iPSC-derived neurons in non-human primatesAsuka Morizane0Tetsuhiro Kikuchi1Takuya Hayashi2Hiroshi Mizuma3Sayuki Takara4Hisashi Doi5Aya Mawatari6Matthew F. Glasser7Takashi Shiina8Hirohito Ishigaki9Yasushi Itoh10Keisuke Okita11Emi Yamasaki12Daisuke Doi13Hirotaka Onoe14Kazumasa Ogasawara15Shinya Yamanaka16Jun Takahashi17Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityRIKEN Center for Life Science Technologies (CLST)RIKEN Center for Life Science Technologies (CLST)RIKEN Center for Life Science Technologies (CLST)RIKEN Center for Life Science Technologies (CLST)RIKEN Center for Life Science Technologies (CLST)Department of Neuroscience, Washington University School of MedicineDepartment of Molecular Life Science, Tokai University, School of MedicineDepartment of Pathology, Shiga University of Medical ScienceDepartment of Pathology, Shiga University of Medical ScienceDepartment of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityRIKEN Center for Life Science Technologies (CLST)Department of Pathology, Shiga University of Medical ScienceDepartment of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityMajor histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.https://doi.org/10.1038/s41467-017-00926-5 |
| spellingShingle | Asuka Morizane Tetsuhiro Kikuchi Takuya Hayashi Hiroshi Mizuma Sayuki Takara Hisashi Doi Aya Mawatari Matthew F. Glasser Takashi Shiina Hirohito Ishigaki Yasushi Itoh Keisuke Okita Emi Yamasaki Daisuke Doi Hirotaka Onoe Kazumasa Ogasawara Shinya Yamanaka Jun Takahashi MHC matching improves engraftment of iPSC-derived neurons in non-human primates Nature Communications |
| title | MHC matching improves engraftment of iPSC-derived neurons in non-human primates |
| title_full | MHC matching improves engraftment of iPSC-derived neurons in non-human primates |
| title_fullStr | MHC matching improves engraftment of iPSC-derived neurons in non-human primates |
| title_full_unstemmed | MHC matching improves engraftment of iPSC-derived neurons in non-human primates |
| title_short | MHC matching improves engraftment of iPSC-derived neurons in non-human primates |
| title_sort | mhc matching improves engraftment of ipsc derived neurons in non human primates |
| url | https://doi.org/10.1038/s41467-017-00926-5 |
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