Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome

Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome

Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with...

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Bibliographic Details
Main Authors: Alain Chebly, Claudia Djambas Khayat, Tony Yammine, Rima Korban, Warde Semaan, Jessica Bou Zeid, Chantal Farra
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Leukemia Research Reports
Subjects:
Acute myeloid leukemia
AML
Septin
MLL
SEPT6
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048921000443
Description
Summary:Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases.
ISSN:2213-0489

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