Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome
Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048921000443 |
| _version_ | 1818925960096907264 |
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| author | Alain Chebly Claudia Djambas Khayat Tony Yammine Rima Korban Warde Semaan Jessica Bou Zeid Chantal Farra |
| author_facet | Alain Chebly Claudia Djambas Khayat Tony Yammine Rima Korban Warde Semaan Jessica Bou Zeid Chantal Farra |
| author_sort | Alain Chebly |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases. |
| first_indexed | 2024-12-20T02:49:31Z |
| format | Article |
| id | doaj.art-3751b9d1ef464ed5aecf299d32bc705e |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-20T02:49:31Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-3751b9d1ef464ed5aecf299d32bc705e2022-12-21T19:56:04ZengElsevierLeukemia Research Reports2213-04892021-01-0116100277Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcomeAlain Chebly0Claudia Djambas Khayat1Tony Yammine2Rima Korban3Warde Semaan4Jessica Bou Zeid5Chantal Farra6Medical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, LebanonDepartment of Pediatrics, Hotel Dieu de France Medical Center, Beirut, LebanonMedical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, LebanonMedical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, LebanonMedical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, LebanonMedical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, LebanonMedical Genetics Unit (UGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon; Department of Genetics, Hotel Dieu de France Medical Center, Beirut, Lebanon; Corresponding author at: Saint Joseph University, Damascus street, B.P. 17-5208, Mar Mikhaël, Beirut, 1104 2020 Beirut, Lebanon.Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases.http://www.sciencedirect.com/science/article/pii/S2213048921000443Acute myeloid leukemiaAMLSeptinMLLSEPT6 |
| spellingShingle | Alain Chebly Claudia Djambas Khayat Tony Yammine Rima Korban Warde Semaan Jessica Bou Zeid Chantal Farra Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome Leukemia Research Reports Acute myeloid leukemia AML Septin MLL SEPT6 |
| title | Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome |
| title_full | Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome |
| title_fullStr | Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome |
| title_full_unstemmed | Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome |
| title_short | Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome |
| title_sort | pediatric m5 acute myeloid leukemia with mll sept6 fusion and a favorable outcome |
| topic | Acute myeloid leukemia AML Septin MLL SEPT6 |
| url | http://www.sciencedirect.com/science/article/pii/S2213048921000443 |
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