Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes
Background: The aim of this study was to find the influence of supplementation with omega-3 plus vitamin E and vitamin C plus zinc on metabolic syndrome components. Methods: In a double-blind controlled clinical trial, 75 diabetic postmenopausal women were randomly assigned to one of the three thera...
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| Format: | Article |
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Kerman University of Medical Sciences
2019-01-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_87273_a5e3b2bbc8100e310cb357bb82dc7d00.pdf |
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| author | Mohammad Reza Mahmoodi Yadollah Mehrabi Masoud Kimiagar Asadollah Rajab |
| author_facet | Mohammad Reza Mahmoodi Yadollah Mehrabi Masoud Kimiagar Asadollah Rajab |
| author_sort | Mohammad Reza Mahmoodi |
| collection | DOAJ |
| description | Background: The aim of this study was to find the influence of supplementation with omega-3 plus vitamin E and vitamin C plus zinc on metabolic syndrome components. Methods: In a double-blind controlled clinical trial, 75 diabetic postmenopausal women were randomly assigned to one of the three therapeutic groups of daily supplementation of 1.8g omega-3 plus 400mg vitamin E (group A), 5mg zinc plus 300mg vitamin C (group B), or placebo (group C) for 12 weeks and the results were evaluated. Results: One-way repeated measures ANOVA showed that systolic and diastolic blood pressure and waist circumference showed significant difference before and after the intervention (p = 0.0001, 0.001, and 0.045, respectively). Results of Univariate ANOVA showed that the level of plasma fasting blood sugar (FBS) and HDL-cholesterol significantly increased (p =0.01 and p =0.03, respectively) in patients who had been diagnosed as diabetic ≤7 years in group B. The plasma TG concentration significantly decreased (p =0.007) in patients who had been diagnosed as diabetic ≤7 years in group A. Systolic and diastolic BP significantly decreased (p =0.005 and p =0.04, respectively) in patients who had been diagnosed as diabetic ≤7 years in group A. The most effectiveness of nutraceutical supplementation was on patients that had been diagnosed as diabetic ≤7 years. Plasma TG and systolic BP decreased with omega-3 plus vitamin E; however, plasma FBS and HDL- cholesterol increased with zinc plus vitamin C supplementation. Conclusion: Several factors, such as duration of diabetes, age, gender, pathophysiology status, genetic, and other anthropometric characteristics may influence the effectiveness of supplementation. |
| first_indexed | 2024-03-13T02:08:55Z |
| format | Article |
| id | doaj.art-3751d2ae1dbf4d61a708243feb0de499 |
| institution | Directory Open Access Journal |
| issn | 2008-2843 |
| language | English |
| last_indexed | 2024-03-13T02:08:55Z |
| publishDate | 2019-01-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-3751d2ae1dbf4d61a708243feb0de4992023-07-01T05:16:06ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432019-01-01261435410.22062/jkmu.2019.8727387273Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetesMohammad Reza Mahmoodi0Yadollah Mehrabi1Masoud Kimiagar2Asadollah Rajab3Physiology Research Center, Institute of Basic and Clinical Physiology & Nutrition Department, School of Health, Kerman University of Medical Sciences. Kerman, IranDepartment of Health and Social Medicine, School of Medicine, Shaheed Beheshti University of Medical Sciences. Tehran, IranHuman Nutrition & Diet Therapy Department, School of Nutrition and Food Technology, Shaheed Beheshti University of Medical Sciences. Tehran, IranIranian Diabetes Society, Malakotti St., Tehran, IranBackground: The aim of this study was to find the influence of supplementation with omega-3 plus vitamin E and vitamin C plus zinc on metabolic syndrome components. Methods: In a double-blind controlled clinical trial, 75 diabetic postmenopausal women were randomly assigned to one of the three therapeutic groups of daily supplementation of 1.8g omega-3 plus 400mg vitamin E (group A), 5mg zinc plus 300mg vitamin C (group B), or placebo (group C) for 12 weeks and the results were evaluated. Results: One-way repeated measures ANOVA showed that systolic and diastolic blood pressure and waist circumference showed significant difference before and after the intervention (p = 0.0001, 0.001, and 0.045, respectively). Results of Univariate ANOVA showed that the level of plasma fasting blood sugar (FBS) and HDL-cholesterol significantly increased (p =0.01 and p =0.03, respectively) in patients who had been diagnosed as diabetic ≤7 years in group B. The plasma TG concentration significantly decreased (p =0.007) in patients who had been diagnosed as diabetic ≤7 years in group A. Systolic and diastolic BP significantly decreased (p =0.005 and p =0.04, respectively) in patients who had been diagnosed as diabetic ≤7 years in group A. The most effectiveness of nutraceutical supplementation was on patients that had been diagnosed as diabetic ≤7 years. Plasma TG and systolic BP decreased with omega-3 plus vitamin E; however, plasma FBS and HDL- cholesterol increased with zinc plus vitamin C supplementation. Conclusion: Several factors, such as duration of diabetes, age, gender, pathophysiology status, genetic, and other anthropometric characteristics may influence the effectiveness of supplementation.https://jkmu.kmu.ac.ir/article_87273_a5e3b2bbc8100e310cb357bb82dc7d00.pdfmetabolic syndrome componentspostmenopausal womensupplementationtype 2 diabetes |
| spellingShingle | Mohammad Reza Mahmoodi Yadollah Mehrabi Masoud Kimiagar Asadollah Rajab Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes Journal of Kerman University of Medical Sciences metabolic syndrome components postmenopausal women supplementation type 2 diabetes |
| title | Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes |
| title_full | Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes |
| title_fullStr | Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes |
| title_full_unstemmed | Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes |
| title_short | Supplementation with omega-3 plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type 2 diabetes |
| title_sort | supplementation with omega 3 plus vitamin e and zinc plus vitamin c on metabolic syndrome components in postmenopausal women with type 2 diabetes |
| topic | metabolic syndrome components postmenopausal women supplementation type 2 diabetes |
| url | https://jkmu.kmu.ac.ir/article_87273_a5e3b2bbc8100e310cb357bb82dc7d00.pdf |
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