Serum inflammatory cytokines comparison in gastric cancer therapy
To compare serum inflammatory cytokines between laparoscopic-assisted and open radical gastrectomy in the perioperative period, 80 cases of advanced gastric cancer were chosen for the study. They were divided into laparoscopy group (40 cases) and abdominal open surgery group (40 cases), performed la...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2019-03-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2019-0027 |
| _version_ | 1811194258984534016 |
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| author | Zhang Li Ren Lehao Shan Keshu Guo Xiaobo Wang Jinshen Cui Bin An Jie |
| author_facet | Zhang Li Ren Lehao Shan Keshu Guo Xiaobo Wang Jinshen Cui Bin An Jie |
| author_sort | Zhang Li |
| collection | DOAJ |
| description | To compare serum inflammatory cytokines between laparoscopic-assisted and open radical gastrectomy in the perioperative period, 80 cases of advanced gastric cancer were chosen for the study. They were divided into laparoscopy group (40 cases) and abdominal open surgery group (40 cases), performed laparoscopic-assisted radical gastrostomy and conventional open radical gastrectomy, respectively. Serum Heme oxygenase-1 (HO-1), TNF-α, IL-6 and CRP were measured by ELISA on preoperative day 1, post-operative day 1 and post-operative day3. Serum HO-1, TNF-α, IL-6 and CRP had no significant difference between the laparoscopy group and the open group on pre-operative day 1. Serum HO-1, IL-6 and CRP of the laparoscopy group were significantly lower than that of the open group on post-operative day 1 and day 3 except for Serum TNF-α which had no significant difference. Laparoscopic-assisted radical gastrectomy was minimally invasive compared with conventional open radical gastrectomy in advanced gastric cancer patients. |
| first_indexed | 2024-04-12T00:23:05Z |
| format | Article |
| id | doaj.art-375235ae00064a0aa51ebb4eccc779e6 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T00:23:05Z |
| publishDate | 2019-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-375235ae00064a0aa51ebb4eccc779e62022-12-22T03:55:36ZengDe GruyterOpen Medicine2391-54632019-03-0114130030610.1515/med-2019-0027med-2019-0027Serum inflammatory cytokines comparison in gastric cancer therapyZhang Li0Ren Lehao1Shan Keshu2Guo Xiaobo3Wang Jinshen4Cui Bin5An Jie6Department of general surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of general surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of general surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of general surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of general surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of general surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, ChinaDepartment of Pharmacology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan, Shandong, 250012P.R. ChinaTo compare serum inflammatory cytokines between laparoscopic-assisted and open radical gastrectomy in the perioperative period, 80 cases of advanced gastric cancer were chosen for the study. They were divided into laparoscopy group (40 cases) and abdominal open surgery group (40 cases), performed laparoscopic-assisted radical gastrostomy and conventional open radical gastrectomy, respectively. Serum Heme oxygenase-1 (HO-1), TNF-α, IL-6 and CRP were measured by ELISA on preoperative day 1, post-operative day 1 and post-operative day3. Serum HO-1, TNF-α, IL-6 and CRP had no significant difference between the laparoscopy group and the open group on pre-operative day 1. Serum HO-1, IL-6 and CRP of the laparoscopy group were significantly lower than that of the open group on post-operative day 1 and day 3 except for Serum TNF-α which had no significant difference. Laparoscopic-assisted radical gastrectomy was minimally invasive compared with conventional open radical gastrectomy in advanced gastric cancer patients.https://doi.org/10.1515/med-2019-0027gastric carcinomalaparoscopeheme oxygenase-1tumor necrosis factor-αinterleukin-6 |
| spellingShingle | Zhang Li Ren Lehao Shan Keshu Guo Xiaobo Wang Jinshen Cui Bin An Jie Serum inflammatory cytokines comparison in gastric cancer therapy Open Medicine gastric carcinoma laparoscope heme oxygenase-1 tumor necrosis factor-α interleukin-6 |
| title | Serum inflammatory cytokines comparison in gastric cancer therapy |
| title_full | Serum inflammatory cytokines comparison in gastric cancer therapy |
| title_fullStr | Serum inflammatory cytokines comparison in gastric cancer therapy |
| title_full_unstemmed | Serum inflammatory cytokines comparison in gastric cancer therapy |
| title_short | Serum inflammatory cytokines comparison in gastric cancer therapy |
| title_sort | serum inflammatory cytokines comparison in gastric cancer therapy |
| topic | gastric carcinoma laparoscope heme oxygenase-1 tumor necrosis factor-α interleukin-6 |
| url | https://doi.org/10.1515/med-2019-0027 |
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