Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors
Abstract Study design Retrospective study. Objectives To explore the incidence and risk factors for symptomatic adjacent segment disease (ASD) in patients enveloped in degenerative lumbar diseases after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Methods Data were retrospec...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-022-05905-6 |
| _version_ | 1811217790946770944 |
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| author | Chao Yuan Jing Zhou Liran Wang Zhongliang Deng |
| author_facet | Chao Yuan Jing Zhou Liran Wang Zhongliang Deng |
| author_sort | Chao Yuan |
| collection | DOAJ |
| description | Abstract Study design Retrospective study. Objectives To explore the incidence and risk factors for symptomatic adjacent segment disease (ASD) in patients enveloped in degenerative lumbar diseases after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Methods Data were retrospectively analyzed on 744 patients who underwent MIS-TLIF for degenerative lumbar diseases in our hospital from October 2012 to December 2018. The patients were divided into the ASD group and non-ASD (N-ASD) group on the basis of developing ASD at follow-up, and then the incidence of ASD was calculated. Clinical and radiological risk factors were assessed over time to determine their association with ASD by excluding less important factors. Results Data were missing for 26 patients, while a total of 718 patients were successfully monitored after MIS-TLIF. Of the 718 individuals participated in the study, 34 (4.7%) patients plagued by ASD required surgical intervention. The average onset time of ASD was 62.7 ± 15.1 months. Univariate analysis results shows that age, bone mineral density (BMD), body mass index (BMI), preoperative adjacent intervertebral disc height and preoperative adjacent segment disc degeneration were significantly different between the ASD and N-ASD groups (p < 0.05). The logistic regression analysis results demonstrated that BMD (p = 0.039, OR = 0.986, 95% CI 0.899–1.115), BMI (p = 0.041, OR = 1.119, 95% CI 1.103–2.397), and preoperative adjacent intervertebral disc degeneration (p = 0.023, OR = 1.215, 95% CI 1.015–1.986) may be seen as risk factors for ASD after MIS-TLIF. Conclusions The incidence of ASD was about 4.7% in patients suffer from degenerative lumbar diseases after MIS-TLIF. BMD, BMI and preoperative adjacent intervertebral disc degeneration might be the risk factors for the occurrence of ASD after MIS-TLIF. Our research also suggested that patients with lower BMD, higher BMI and disc preoperative adjacent segment disc degeneration were more likely to develop ASD after MIS-TLIF. |
| first_indexed | 2024-04-12T07:00:12Z |
| format | Article |
| id | doaj.art-3752f7ce981f45e0804ac7674829ee1d |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-12T07:00:12Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-3752f7ce981f45e0804ac7674829ee1d2022-12-22T03:43:01ZengBMCBMC Musculoskeletal Disorders1471-24742022-11-012311810.1186/s12891-022-05905-6Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factorsChao Yuan0Jing Zhou1Liran Wang2Zhongliang Deng3Department of Orthopaedics, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Orthopaedic Surgery, Affiliated Xinqiao Hospital, Army Medical UniversityDepartment of Orthopaedic Surgery, Affiliated Xinqiao Hospital, Army Medical UniversityDepartment of Orthopaedics, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract Study design Retrospective study. Objectives To explore the incidence and risk factors for symptomatic adjacent segment disease (ASD) in patients enveloped in degenerative lumbar diseases after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Methods Data were retrospectively analyzed on 744 patients who underwent MIS-TLIF for degenerative lumbar diseases in our hospital from October 2012 to December 2018. The patients were divided into the ASD group and non-ASD (N-ASD) group on the basis of developing ASD at follow-up, and then the incidence of ASD was calculated. Clinical and radiological risk factors were assessed over time to determine their association with ASD by excluding less important factors. Results Data were missing for 26 patients, while a total of 718 patients were successfully monitored after MIS-TLIF. Of the 718 individuals participated in the study, 34 (4.7%) patients plagued by ASD required surgical intervention. The average onset time of ASD was 62.7 ± 15.1 months. Univariate analysis results shows that age, bone mineral density (BMD), body mass index (BMI), preoperative adjacent intervertebral disc height and preoperative adjacent segment disc degeneration were significantly different between the ASD and N-ASD groups (p < 0.05). The logistic regression analysis results demonstrated that BMD (p = 0.039, OR = 0.986, 95% CI 0.899–1.115), BMI (p = 0.041, OR = 1.119, 95% CI 1.103–2.397), and preoperative adjacent intervertebral disc degeneration (p = 0.023, OR = 1.215, 95% CI 1.015–1.986) may be seen as risk factors for ASD after MIS-TLIF. Conclusions The incidence of ASD was about 4.7% in patients suffer from degenerative lumbar diseases after MIS-TLIF. BMD, BMI and preoperative adjacent intervertebral disc degeneration might be the risk factors for the occurrence of ASD after MIS-TLIF. Our research also suggested that patients with lower BMD, higher BMI and disc preoperative adjacent segment disc degeneration were more likely to develop ASD after MIS-TLIF.https://doi.org/10.1186/s12891-022-05905-6Adjacent segment diseaseMinimally invasive transforaminal lumbar interbody fusionDegenerative lumbar diseasesRisk factors |
| spellingShingle | Chao Yuan Jing Zhou Liran Wang Zhongliang Deng Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors BMC Musculoskeletal Disorders Adjacent segment disease Minimally invasive transforaminal lumbar interbody fusion Degenerative lumbar diseases Risk factors |
| title | Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors |
| title_full | Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors |
| title_fullStr | Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors |
| title_full_unstemmed | Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors |
| title_short | Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors |
| title_sort | adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases incidence and risk factors |
| topic | Adjacent segment disease Minimally invasive transforaminal lumbar interbody fusion Degenerative lumbar diseases Risk factors |
| url | https://doi.org/10.1186/s12891-022-05905-6 |
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