Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes
The purpose of this study was to investigate the impact of the drug loading method on drug release from 3D-printed tablets. Filaments comprising a poorly water-soluble model drug, indomethacin (IND), and a polymer, polyvinyl alcohol (PVA), were prepared by hot-melt extrusion (HME) and compared with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/10/1607 |
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| author | Kasitpong Thanawuth Lalinthip Sutthapitaksakul Srisuda Konthong Supakij Suttiruengwong Kampanart Huanbutta Crispin R. Dass Pornsak Sriamornsak |
| author_facet | Kasitpong Thanawuth Lalinthip Sutthapitaksakul Srisuda Konthong Supakij Suttiruengwong Kampanart Huanbutta Crispin R. Dass Pornsak Sriamornsak |
| author_sort | Kasitpong Thanawuth |
| collection | DOAJ |
| description | The purpose of this study was to investigate the impact of the drug loading method on drug release from 3D-printed tablets. Filaments comprising a poorly water-soluble model drug, indomethacin (IND), and a polymer, polyvinyl alcohol (PVA), were prepared by hot-melt extrusion (HME) and compared with IND-loaded filaments prepared with an impregnation (IMP) process. The 3D-printed tablets were fabricated using a fused deposition modeling 3D printer. The filaments and 3D printed tablets were evaluated for their physicochemical properties, swelling and matrix erosion behaviors, drug content, and drug release. Physicochemical investigations revealed no drug–excipient interaction or degradation. IND-loaded PVA filaments produced by IMP had a low drug content and a rapid drug release. Filaments produced by HME with a lower drug content released the drug faster than those with a higher drug content. The drug content and drug release of 3D-printed tablets containing IND were similar to those of the filament results. Particularly, drug release was faster in 3D-printed tablets produced with filaments with lower drug content (both by IMP and HME). The drug release of 3D-printed tablets produced from HME filaments with higher drug content was extended to 24 h due to a swelling-erosion process. This study confirmed that the drug loading method has a substantial influence on drug content, which in turn has a significant effect on drug release. The results suggest that increasing the drug content in filaments might delay drug release from 3D-printed tablets, which may be used for developing dosage forms suited for personalized medicine. |
| first_indexed | 2024-03-10T06:16:06Z |
| format | Article |
| id | doaj.art-37540ab5927d4e99bacb26223c1c7dc1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T06:16:06Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-37540ab5927d4e99bacb26223c1c7dc12023-11-22T19:38:25ZengMDPI AGPharmaceutics1999-49232021-10-011310160710.3390/pharmaceutics13101607Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation ProcessesKasitpong Thanawuth0Lalinthip Sutthapitaksakul1Srisuda Konthong2Supakij Suttiruengwong3Kampanart Huanbutta4Crispin R. Dass5Pornsak Sriamornsak6Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandPharmaceutical Biopolymer Group (PBiG), Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom 73000, ThailandPharmaceutical Biopolymer Group (PBiG), Silpakorn University, Nakhon Pathom 73000, ThailandCurtin Medical School, Faculty of Health Sciences, Curtin University, Perth 6845, AustraliaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandThe purpose of this study was to investigate the impact of the drug loading method on drug release from 3D-printed tablets. Filaments comprising a poorly water-soluble model drug, indomethacin (IND), and a polymer, polyvinyl alcohol (PVA), were prepared by hot-melt extrusion (HME) and compared with IND-loaded filaments prepared with an impregnation (IMP) process. The 3D-printed tablets were fabricated using a fused deposition modeling 3D printer. The filaments and 3D printed tablets were evaluated for their physicochemical properties, swelling and matrix erosion behaviors, drug content, and drug release. Physicochemical investigations revealed no drug–excipient interaction or degradation. IND-loaded PVA filaments produced by IMP had a low drug content and a rapid drug release. Filaments produced by HME with a lower drug content released the drug faster than those with a higher drug content. The drug content and drug release of 3D-printed tablets containing IND were similar to those of the filament results. Particularly, drug release was faster in 3D-printed tablets produced with filaments with lower drug content (both by IMP and HME). The drug release of 3D-printed tablets produced from HME filaments with higher drug content was extended to 24 h due to a swelling-erosion process. This study confirmed that the drug loading method has a substantial influence on drug content, which in turn has a significant effect on drug release. The results suggest that increasing the drug content in filaments might delay drug release from 3D-printed tablets, which may be used for developing dosage forms suited for personalized medicine.https://www.mdpi.com/1999-4923/13/10/16073D-printed tablethot-melt extrusionimpregnationpolyvinyl alcoholindomethacinfilament |
| spellingShingle | Kasitpong Thanawuth Lalinthip Sutthapitaksakul Srisuda Konthong Supakij Suttiruengwong Kampanart Huanbutta Crispin R. Dass Pornsak Sriamornsak Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes Pharmaceutics 3D-printed tablet hot-melt extrusion impregnation polyvinyl alcohol indomethacin filament |
| title | Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes |
| title_full | Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes |
| title_fullStr | Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes |
| title_full_unstemmed | Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes |
| title_short | Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes |
| title_sort | impact of drug loading method on drug release from 3d printed tablets made from filaments fabricated by hot melt extrusion and impregnation processes |
| topic | 3D-printed tablet hot-melt extrusion impregnation polyvinyl alcohol indomethacin filament |
| url | https://www.mdpi.com/1999-4923/13/10/1607 |
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