Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes

Impact of Drug Loading Method on Drug Release from 3D-Printed Tablets Made from Filaments Fabricated by Hot-Melt Extrusion and Impregnation Processes

The purpose of this study was to investigate the impact of the drug loading method on drug release from 3D-printed tablets. Filaments comprising a poorly water-soluble model drug, indomethacin (IND), and a polymer, polyvinyl alcohol (PVA), were prepared by hot-melt extrusion (HME) and compared with...

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Bibliographic Details
Main Authors: Kasitpong Thanawuth, Lalinthip Sutthapitaksakul, Srisuda Konthong, Supakij Suttiruengwong, Kampanart Huanbutta, Crispin R. Dass, Pornsak Sriamornsak
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
3D-printed tablet
hot-melt extrusion
impregnation
polyvinyl alcohol
indomethacin
filament
Online Access:https://www.mdpi.com/1999-4923/13/10/1607

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