Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery?
Background: We sought to determine whether abnormal pre-operative platelet counts are associated with increased major adverse cardiovascular events (MACE) in South African (SA) non-cardiac surgery settings. Methods: This was a propensity matched case-control study of data from 150 SA non-cardiac sur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Light House Polyclinic Mangalore
2018-10-01
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| Series: | Online Journal of Health & Allied Sciences |
| Subjects: | |
| Online Access: | https://www.ojhas.org/issue67/2018-3-4.html |
| _version_ | 1828472406972301312 |
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| author | Kroshlan Kistan Yoshan Moodley |
| author_facet | Kroshlan Kistan Yoshan Moodley |
| author_sort | Kroshlan Kistan |
| collection | DOAJ |
| description | Background: We sought to determine whether abnormal pre-operative platelet counts are associated with increased major adverse cardiovascular events (MACE) in South African (SA) non-cardiac surgery settings. Methods: This was a propensity matched case-control study of data from 150 SA non-cardiac surgery patients. Patients had their data (age, gender, cardiovascular risk factors and pre-operative platelet counts) collected as part of a pre-existing registry. Cases were patients with post-operative MACE (post-operative stroke, myocardial infarction or all-cause mortality). Controls were patients without post-operative MACE. Data were analysed using conventional methods for matched case-control studies. Results: Our most important finding was that the odds of post-operative MACE were six-fold higher in patients with pre-operative thrombocytopenia (low platelet count) when compared to patients with normal pre-operative platelet counts (Odds Ratio, OR: 6.28, 95% Confidence Interval, CI: 1.19-33.12; p=0.031). Conclusion: Thrombocytopenia is a risk factor for post-operative MACE in SA non-cardiac surgery patients. |
| first_indexed | 2024-12-11T05:29:26Z |
| format | Article |
| id | doaj.art-37542f55bd58465c96db1b859816ac7f |
| institution | Directory Open Access Journal |
| issn | 0972-5997 0972-5997 |
| language | English |
| last_indexed | 2024-12-11T05:29:26Z |
| publishDate | 2018-10-01 |
| publisher | Light House Polyclinic Mangalore |
| record_format | Article |
| series | Online Journal of Health & Allied Sciences |
| spelling | doaj.art-37542f55bd58465c96db1b859816ac7f2022-12-22T01:19:28ZengLight House Polyclinic MangaloreOnline Journal of Health & Allied Sciences0972-59970972-59972018-10-01173Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery?Kroshlan Kistan0Yoshan Moodley1Anaesthesiology Registrar, Discipline of Anaesthesiology and Critical Care Medicine, Nelson R. Mandela School of Medicine, University of KwaZulu Natal, Durban, South AfricaResearch Fellow, Discipline of Anaesthesiology and Critical Care Medicine, Nelson R. Mandela School of Medicine, University of KwaZulu Natal, Durban, South AfricaBackground: We sought to determine whether abnormal pre-operative platelet counts are associated with increased major adverse cardiovascular events (MACE) in South African (SA) non-cardiac surgery settings. Methods: This was a propensity matched case-control study of data from 150 SA non-cardiac surgery patients. Patients had their data (age, gender, cardiovascular risk factors and pre-operative platelet counts) collected as part of a pre-existing registry. Cases were patients with post-operative MACE (post-operative stroke, myocardial infarction or all-cause mortality). Controls were patients without post-operative MACE. Data were analysed using conventional methods for matched case-control studies. Results: Our most important finding was that the odds of post-operative MACE were six-fold higher in patients with pre-operative thrombocytopenia (low platelet count) when compared to patients with normal pre-operative platelet counts (Odds Ratio, OR: 6.28, 95% Confidence Interval, CI: 1.19-33.12; p=0.031). Conclusion: Thrombocytopenia is a risk factor for post-operative MACE in SA non-cardiac surgery patients.https://www.ojhas.org/issue67/2018-3-4.htmlPlateletsNon-cardiac surgeryCardiovascular complicationsSouth Africa |
| spellingShingle | Kroshlan Kistan Yoshan Moodley Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery? Online Journal of Health & Allied Sciences Platelets Non-cardiac surgery Cardiovascular complications South Africa |
| title | Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery? |
| title_full | Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery? |
| title_fullStr | Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery? |
| title_full_unstemmed | Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery? |
| title_short | Are Abnormal Pre-operative Platelet Counts a Risk Factor for Major Adverse Cardiovascular Events Following Non-cardiac Surgery? |
| title_sort | are abnormal pre operative platelet counts a risk factor for major adverse cardiovascular events following non cardiac surgery |
| topic | Platelets Non-cardiac surgery Cardiovascular complications South Africa |
| url | https://www.ojhas.org/issue67/2018-3-4.html |
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