Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease
Sporadic Alzheimer’s disease (AD) is a severe disorder of unknown etiology with no definite time frame of onset. Recent studies suggest that middle age is a critical period for the relevant pathological processes of AD. Nonetheless, sufficient data have accumulated supporting the hypothesis of “neur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/7/823 |
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| author | Ekaterina A. Rudnitskaya Tatiana A. Kozlova Alena O. Burnyasheva Natalia A. Stefanova Nataliya G. Kolosova |
| author_facet | Ekaterina A. Rudnitskaya Tatiana A. Kozlova Alena O. Burnyasheva Natalia A. Stefanova Nataliya G. Kolosova |
| author_sort | Ekaterina A. Rudnitskaya |
| collection | DOAJ |
| description | Sporadic Alzheimer’s disease (AD) is a severe disorder of unknown etiology with no definite time frame of onset. Recent studies suggest that middle age is a critical period for the relevant pathological processes of AD. Nonetheless, sufficient data have accumulated supporting the hypothesis of “neurodevelopmental origin of neurodegenerative disorders”: prerequisites for neurodegeneration may occur during early brain development. Therefore, we investigated the development of the most AD-affected brain structures (hippocampus and prefrontal cortex) using an immunohistochemical approach in senescence-accelerated OXYS rats, which are considered a suitable model of the most common—sporadic—type of AD. We noticed an additional peak of neurogenesis, which coincides in time with the peak of apoptosis in the hippocampus of OXYS rats on postnatal day three. Besides, we showed signs of delayed migration of neurons to the prefrontal cortex as well as disturbances in astrocytic and microglial support of the hippocampus and prefrontal cortex during the first postnatal week. Altogether, our results point to dysmaturation during early development of the brain—especially insufficient glial support—as a possible “first hit” leading to neurodegenerative processes and AD pathology manifestation later in life. |
| first_indexed | 2024-03-10T09:44:49Z |
| format | Article |
| id | doaj.art-37543dbbf808423ab62e0775c8381721 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T09:44:49Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-37543dbbf808423ab62e0775c83817212023-11-22T03:17:36ZengMDPI AGBiomedicines2227-90592021-07-019782310.3390/biomedicines9070823Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s DiseaseEkaterina A. Rudnitskaya0Tatiana A. Kozlova1Alena O. Burnyasheva2Natalia A. Stefanova3Nataliya G. Kolosova4Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Lavrentyeva Ave., 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Lavrentyeva Ave., 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Lavrentyeva Ave., 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Lavrentyeva Ave., 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Lavrentyeva Ave., 630090 Novosibirsk, RussiaSporadic Alzheimer’s disease (AD) is a severe disorder of unknown etiology with no definite time frame of onset. Recent studies suggest that middle age is a critical period for the relevant pathological processes of AD. Nonetheless, sufficient data have accumulated supporting the hypothesis of “neurodevelopmental origin of neurodegenerative disorders”: prerequisites for neurodegeneration may occur during early brain development. Therefore, we investigated the development of the most AD-affected brain structures (hippocampus and prefrontal cortex) using an immunohistochemical approach in senescence-accelerated OXYS rats, which are considered a suitable model of the most common—sporadic—type of AD. We noticed an additional peak of neurogenesis, which coincides in time with the peak of apoptosis in the hippocampus of OXYS rats on postnatal day three. Besides, we showed signs of delayed migration of neurons to the prefrontal cortex as well as disturbances in astrocytic and microglial support of the hippocampus and prefrontal cortex during the first postnatal week. Altogether, our results point to dysmaturation during early development of the brain—especially insufficient glial support—as a possible “first hit” leading to neurodegenerative processes and AD pathology manifestation later in life.https://www.mdpi.com/2227-9059/9/7/823neurogenesisneurongliapostnatal developmenthippocampusprefrontal cortex |
| spellingShingle | Ekaterina A. Rudnitskaya Tatiana A. Kozlova Alena O. Burnyasheva Natalia A. Stefanova Nataliya G. Kolosova Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease Biomedicines neurogenesis neuron glia postnatal development hippocampus prefrontal cortex |
| title | Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease |
| title_full | Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease |
| title_fullStr | Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease |
| title_full_unstemmed | Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease |
| title_short | Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer’s Disease |
| title_sort | glia not neurons uncovering brain dysmaturation in a rat model of alzheimer s disease |
| topic | neurogenesis neuron glia postnatal development hippocampus prefrontal cortex |
| url | https://www.mdpi.com/2227-9059/9/7/823 |
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