Identifying promising druggable binding sites and their flexibility to target the receptor-binding domain of SARS-CoV-2 spike protein

Identifying promising druggable binding sites and their flexibility to target the receptor-binding domain of SARS-CoV-2 spike protein

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for viral infection. The interaction of its receptor-binding domain (RBD) with the human angiotensin-converting enzyme 2 (ACE2) protein is required for the virus to enter the host cell. We identified RBD bin...

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Bibliographic Details
Main Authors: M. Ghoula, S. Naceri, S. Sitruk, D. Flatters, G. Moroy, A.C. Camproux
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV-2
Spike protein
Structural flexibility
Hot spot residues
Pocket tracking
Binding site flexibility
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023001290

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http://www.sciencedirect.com/science/article/pii/S2001037023001290

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