Identification of Key Small Non‐Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Identification of Key Small Non‐Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca2+‐handling proteins. MicroRNAs (miRs) inhibit gene expression. The role of...

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Bibliographic Details
Main Authors: Maria Petkova, Andrew J. Atkinson, Joseph Yanni, Luke Stuart, Abimbola J. Aminu, Alexandra D. Ivanova, Ksenia B. Pustovit, Connor Geragthy, Amy Feather, Ning Li, Yu Zhang, Delvac Oceandy, Filip Perde, Peter Molenaar, Alicia D’Souza, Vadim V. Fedorov, Halina Dobrzynski
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
ion channels
microRNAs
pacemaker of the heart
sinus node disease
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016590

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