One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP<sub>8</sub> Occurs under Cytosolic Conditions

One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP<sub>8</sub> Occurs under Cytosolic Conditions

Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are central eukaryotic messengers. These very highly phosphorylated molecules can exist in two distinct conformations, a canonical one with five phosphoryl groups in equatorial positions, and a “flipped” conformation with five axial substituents...

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Bibliographic Details
Main Authors: Leonie Kurz, Peter Schmieder, Nicolás Veiga, Dorothea Fiedler
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomolecules
Subjects:
InsP<sub>8</sub>
inositol pyrophosphates
conformation
NMR
ring-flip
molecular switch
Online Access:https://www.mdpi.com/2218-273X/13/4/645

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