Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives
Primary varicella-zoster virus (VZV) infection causes varicella, which remains a prominent public health concern in children. Current varicella vaccines adopt the live-attenuated Oka strain, vOka, which retains the ability to infect neurons, establish latency and reactivate, leading to vaccine-assoc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/5/848 |
| _version_ | 1797494706702123008 |
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| author | Wei Wang Dequan Pan Tong Cheng Hua Zhu |
| author_facet | Wei Wang Dequan Pan Tong Cheng Hua Zhu |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Primary varicella-zoster virus (VZV) infection causes varicella, which remains a prominent public health concern in children. Current varicella vaccines adopt the live-attenuated Oka strain, vOka, which retains the ability to infect neurons, establish latency and reactivate, leading to vaccine-associated zoster in some vaccinees. Therefore, it is necessary to develop a safer next-generation varicella vaccine to help reduce vaccine hesitancy. This paper reviews the discovery and identification of the skin- and neuro-tropic factor, the open reading frame 7 (<i>ORF7</i>) of VZV, as well as the development of a skin- and neuro-attenuated live varicella vaccine comprising an <i>ORF7</i>-deficient mutant, v7D. This work could provide insights into the research of novel virus vaccines based on functional genomics and reverse genetics. |
| first_indexed | 2024-03-10T01:38:12Z |
| format | Article |
| id | doaj.art-375594c8d9b8431b97a9ca8a118df52e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T01:38:12Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-375594c8d9b8431b97a9ca8a118df52e2023-11-23T13:29:04ZengMDPI AGViruses1999-49152022-04-0114584810.3390/v14050848Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future PerspectivesWei Wang0Dequan Pan1Tong Cheng2Hua Zhu3State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen 361102, ChinaDepartment of Microbiology and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, NJ 070101, USAPrimary varicella-zoster virus (VZV) infection causes varicella, which remains a prominent public health concern in children. Current varicella vaccines adopt the live-attenuated Oka strain, vOka, which retains the ability to infect neurons, establish latency and reactivate, leading to vaccine-associated zoster in some vaccinees. Therefore, it is necessary to develop a safer next-generation varicella vaccine to help reduce vaccine hesitancy. This paper reviews the discovery and identification of the skin- and neuro-tropic factor, the open reading frame 7 (<i>ORF7</i>) of VZV, as well as the development of a skin- and neuro-attenuated live varicella vaccine comprising an <i>ORF7</i>-deficient mutant, v7D. This work could provide insights into the research of novel virus vaccines based on functional genomics and reverse genetics.https://www.mdpi.com/1999-4915/14/5/848varicella-zoster virusvaricellaVZVneuro-attenuatedORF7vaccine |
| spellingShingle | Wei Wang Dequan Pan Tong Cheng Hua Zhu Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives Viruses varicella-zoster virus varicella VZV neuro-attenuated ORF7 vaccine |
| title | Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives |
| title_full | Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives |
| title_fullStr | Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives |
| title_full_unstemmed | Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives |
| title_short | Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives |
| title_sort | rational design of a skin and neuro attenuated live varicella vaccine a review and future perspectives |
| topic | varicella-zoster virus varicella VZV neuro-attenuated ORF7 vaccine |
| url | https://www.mdpi.com/1999-4915/14/5/848 |
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