The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes
Teonchit Nuamchit, Duangduan Siriwittayawan, Piyanuch Thitiwuthikiat Department of Cardiothoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, ThailandCorrespondence: Piyanuch ThitiwuthikiatDepartment of Cardiothoracic Technology, Faculty of Allied Health Sciences...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-08-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-relationship-between-glycemic-control-and-concomitant-hypertension-peer-reviewed-article-VHRM |
| _version_ | 1819228317956440064 |
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| author | Nuamchit T Siriwittayawan D Thitiwuthikiat P |
| author_facet | Nuamchit T Siriwittayawan D Thitiwuthikiat P |
| author_sort | Nuamchit T |
| collection | DOAJ |
| description | Teonchit Nuamchit, Duangduan Siriwittayawan, Piyanuch Thitiwuthikiat Department of Cardiothoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, ThailandCorrespondence: Piyanuch ThitiwuthikiatDepartment of Cardiothoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Thapho, Muang, Phitsanulok 65000, ThailandTel +66 55 966 371Fax +66 55 966 234Email piyanucht@nu.ac.thPurpose: The impact of glycemic control on macrovascular complications and arterial stiffness in type II diabetes (T2D), as well as the extent of additive effect of hypertension, is unclear. The aims of this study were to investigate the impact of glycemic control on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness, and to determine the relative risk of concomitant diabetes and hypertension with arterial stiffness.Methods: One hundred and nine participants were enrolled and classified as non-diabetes (n= 37) and diabetes (n=72); the diabetic group was further identified as controllable and uncontrollable T2D depending on their hemoglobin A1c (HbA1c) levels. Univariate and multiple regression analyses were used to assess the association between CAVI and glycemic control status and hypertension. Relative risk analysis for abnormal CAVI with exposure to diabetes and hypertension was investigated.Results: In all participants, age, systolic blood pressure, body mass index, and fasting blood sugar were independent predictors of CAVI. In diabetic participants, glycemic control status or HbA1c levels did not significantly correlate with CAVI. Systolic blood pressure was an independent predictor for CAVI with β = 0.26. In addition, the coexistence of diabetes together with hypertension was significantly associated with a 2.4-fold increase in the risk of abnormal CAVI (95% CI, 1.410– 4.184; p < 0.001).Conclusion: This study demonstrates that HbA1c as well as fasting blood sugar levels in diabetic participants do not correlate with arterial stiffness. Concomitant diabetes and hypertension significantly increase the risk of arterial stiffness.Keywords: arterial stiffness, cardio-ankle vascular index, diabetes, glycemic control, hypertension |
| first_indexed | 2024-12-23T10:55:22Z |
| format | Article |
| id | doaj.art-37573ffe0fed4ca9a67da924ef4fda5c |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-23T10:55:22Z |
| publishDate | 2020-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-37573ffe0fed4ca9a67da924ef4fda5c2022-12-21T17:49:47ZengDove Medical PressVascular Health and Risk Management1178-20482020-08-01Volume 1634335256586The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II DiabetesNuamchit TSiriwittayawan DThitiwuthikiat PTeonchit Nuamchit, Duangduan Siriwittayawan, Piyanuch Thitiwuthikiat Department of Cardiothoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, ThailandCorrespondence: Piyanuch ThitiwuthikiatDepartment of Cardiothoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Thapho, Muang, Phitsanulok 65000, ThailandTel +66 55 966 371Fax +66 55 966 234Email piyanucht@nu.ac.thPurpose: The impact of glycemic control on macrovascular complications and arterial stiffness in type II diabetes (T2D), as well as the extent of additive effect of hypertension, is unclear. The aims of this study were to investigate the impact of glycemic control on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness, and to determine the relative risk of concomitant diabetes and hypertension with arterial stiffness.Methods: One hundred and nine participants were enrolled and classified as non-diabetes (n= 37) and diabetes (n=72); the diabetic group was further identified as controllable and uncontrollable T2D depending on their hemoglobin A1c (HbA1c) levels. Univariate and multiple regression analyses were used to assess the association between CAVI and glycemic control status and hypertension. Relative risk analysis for abnormal CAVI with exposure to diabetes and hypertension was investigated.Results: In all participants, age, systolic blood pressure, body mass index, and fasting blood sugar were independent predictors of CAVI. In diabetic participants, glycemic control status or HbA1c levels did not significantly correlate with CAVI. Systolic blood pressure was an independent predictor for CAVI with β = 0.26. In addition, the coexistence of diabetes together with hypertension was significantly associated with a 2.4-fold increase in the risk of abnormal CAVI (95% CI, 1.410– 4.184; p < 0.001).Conclusion: This study demonstrates that HbA1c as well as fasting blood sugar levels in diabetic participants do not correlate with arterial stiffness. Concomitant diabetes and hypertension significantly increase the risk of arterial stiffness.Keywords: arterial stiffness, cardio-ankle vascular index, diabetes, glycemic control, hypertensionhttps://www.dovepress.com/the-relationship-between-glycemic-control-and-concomitant-hypertension-peer-reviewed-article-VHRMarterial stiffnesscardio-ankle vascular indexdiabetesglycemic controlhypertension |
| spellingShingle | Nuamchit T Siriwittayawan D Thitiwuthikiat P The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes Vascular Health and Risk Management arterial stiffness cardio-ankle vascular index diabetes glycemic control hypertension |
| title | The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes |
| title_full | The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes |
| title_fullStr | The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes |
| title_full_unstemmed | The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes |
| title_short | The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes |
| title_sort | relationship between glycemic control and concomitant hypertension on arterial stiffness in type ii diabetes |
| topic | arterial stiffness cardio-ankle vascular index diabetes glycemic control hypertension |
| url | https://www.dovepress.com/the-relationship-between-glycemic-control-and-concomitant-hypertension-peer-reviewed-article-VHRM |
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