Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes

Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes

Talaromyces marneffei tends to induce systemic infection in immunocompromised individuals, which is one of the causes of the high mortality. The underlying molecular mechanisms of T.marneffei-induced abnormal liver function are still poorly understood. In this study, we found that T.marneffei-infect...

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Bibliographic Details
Main Authors: Gang Wang, Wudi Wei, Zhongsheng Jiang, Junjun Jiang, Jing Han, Hong Zhang, Jiaguang Hu, Peng Zhang, Xu Li, Tao Chen, Jinhao He, Zhen Li, Jingzhen Lai, Hao Liang, Chuanyi Ning, Li Ye
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Virulence
Subjects:
Talaromyces marneffei
liver damage
pyroptosis
inflammation
opportunistic infection
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2022.2080904

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