Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems
The capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-08-01
|
| Series: | Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2504-3900/1/4/278 |
| _version_ | 1811273776247078912 |
|---|---|
| author | Adam Lewis Nick Harris |
| author_facet | Adam Lewis Nick Harris |
| author_sort | Adam Lewis |
| collection | DOAJ |
| description | The capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an electrode located close to the capillary surface it is possible to dynamically modify zeta-potential and therefore the electroosmotic flow (EOF). By controlling the EOF, certain ionic species within a sample can be held in a short channel whilst other species migrate along the channel. Alternatively the sample can be transported back and forth along the active channel length until sufficient separation has been attained. CE enables detailed analysis of a sample’s composition and this is of interest to a range of applications. |
| first_indexed | 2024-04-12T23:05:38Z |
| format | Article |
| id | doaj.art-3757577d41b44c2a96ccc501a6cdf68d |
| institution | Directory Open Access Journal |
| issn | 2504-3900 |
| language | English |
| last_indexed | 2024-04-12T23:05:38Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-3757577d41b44c2a96ccc501a6cdf68d2022-12-22T03:12:55ZengMDPI AGProceedings2504-39002017-08-011427810.3390/proceedings1040278proceedings1040278Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis SystemsAdam Lewis0Nick Harris1Electronics and Computer Science, University of Southampton, Southampton, UKElectronics and Computer Science, University of Southampton, Southampton, UKThe capillary/channel length is an important factor in capillary electrophoresis (CE) systems since it is directly related to the amount of separation attainable. In this work we present methods to increase the effective channel length without the need to modify the physical channel length. Using an electrode located close to the capillary surface it is possible to dynamically modify zeta-potential and therefore the electroosmotic flow (EOF). By controlling the EOF, certain ionic species within a sample can be held in a short channel whilst other species migrate along the channel. Alternatively the sample can be transported back and forth along the active channel length until sufficient separation has been attained. CE enables detailed analysis of a sample’s composition and this is of interest to a range of applications.https://www.mdpi.com/2504-3900/1/4/278capillary electrophoresismicrofluidic modellingseparation enhancement |
| spellingShingle | Adam Lewis Nick Harris Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems Proceedings capillary electrophoresis microfluidic modelling separation enhancement |
| title | Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems |
| title_full | Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems |
| title_fullStr | Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems |
| title_full_unstemmed | Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems |
| title_short | Modelling New Techniques for Improving Separation in Miniature Capillary- and Planar-Based Capillary Electrophoresis Systems |
| title_sort | modelling new techniques for improving separation in miniature capillary and planar based capillary electrophoresis systems |
| topic | capillary electrophoresis microfluidic modelling separation enhancement |
| url | https://www.mdpi.com/2504-3900/1/4/278 |
| work_keys_str_mv | AT adamlewis modellingnewtechniquesforimprovingseparationinminiaturecapillaryandplanarbasedcapillaryelectrophoresissystems AT nickharris modellingnewtechniquesforimprovingseparationinminiaturecapillaryandplanarbasedcapillaryelectrophoresissystems |