Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids
In dairy operations, antibiotics have traditionally been used to treat, prevent, and control diseases. However, given the mounting global crisis of antimicrobial resistance (AMR), farmers are urged to re-assess and reduce their reliance on antibiotics. Thus, this randomized, double-blinded cohort st...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Animal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731123003579 |
| _version_ | 1797355273974710272 |
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| author | F. Zamuner E.K. Carpenter H. Gebrekidan G. Arcos-Gómez A. Parkinson A.W.N. Cameron B.J. Leury K. DiGiacomo |
| author_facet | F. Zamuner E.K. Carpenter H. Gebrekidan G. Arcos-Gómez A. Parkinson A.W.N. Cameron B.J. Leury K. DiGiacomo |
| author_sort | F. Zamuner |
| collection | DOAJ |
| description | In dairy operations, antibiotics have traditionally been used to treat, prevent, and control diseases. However, given the mounting global crisis of antimicrobial resistance (AMR), farmers are urged to re-assess and reduce their reliance on antibiotics. Thus, this randomized, double-blinded cohort study aimed to estimate the prevalence of failed and successful transfer of passive immunity (FTPI and STPI) in dairy goat kids reared under commercial conditions, and the effects of antibiotic metaphylaxis on the pre-weaning (≤42 d old) mortality in FTPI and STPI kids. Plasma concentration of immunoglobulin G at 1d old (pIgG-24 h) was measured in 747 male Saanen kids for the determination of FTPI and STPI (pIgG-24 h < 12 and ≥12 g/L, respectively). Kids were then randomly divided into two groups: those receiving a single penicillin injection at 1 d old (PEN), and those receiving no treatment (CTR). The mean (±SD) pIgG-24 h and initial BW (IBW) were 17 ± 9.8 g/L and 4.1 ± 0.64 kg. The prevalence of FTPI was 29% (220/747 kids). Gastrointestinal complications were the primary cause of death (41%), followed by septicemia (22%) and arthritis (17%). A single penicillin injection reduced preweaning mortality by 55% (10 vs 22%, PEN vs CTR). However, results suggest that such a decline was mainly driven by the improved survival rates among FTPI kids, which increased by 19% (from 62% in CTR-FTPI to 82% in PEN-FTPI), as opposed to an 8% increase among STPI kids (from 85% in CTR-STPI to 93% in PEN-STPI). Additionally, the odds of mortality ≤ 42 d old were threefold higher in the CTR-FTPI group when compared to both the CTR-STPI and PEN-FTPI groups, suggesting a potential parity between STPI and PEN for mortality rate reduction. Taken together, the results indicate that although metaphylactic antibiotics can halve preweaning mortality, similar improvements are likely to be achieved via increased STPI rates. Furthermore, by targeting metaphylactic interventions to high-risk groups (i.e., those displaying signs of inadequate colostrum intake and/or low birth BW), farmers could reduce treatment costs and mitigate AMR risks. While these findings carry considerable weight for commercial dairy goat practices, their applicability to other systems (i.e., extensive, semi-intensive, mohair, meat systems) warrants further investigation. |
| first_indexed | 2024-03-08T14:08:47Z |
| format | Article |
| id | doaj.art-3757fad40aef42e4a38e029971f2d80a |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-03-08T14:08:47Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-3757fad40aef42e4a38e029971f2d80a2024-01-15T04:20:59ZengElsevierAnimal1751-73112024-01-01181101040Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kidsF. Zamuner0E.K. Carpenter1H. Gebrekidan2G. Arcos-Gómez3A. Parkinson4A.W.N. Cameron5B.J. Leury6K. DiGiacomo7School of Agriculture, Food and Ecosystem Sciences, Faculty of Science – The University of Melbourne, Parkville, Victoria 3010, Australia; Corresponding author.Meredith Dairy Pty Ltd., 106 Cameron Rd, Meredith, Victoria 3333, AustraliaMeredith Dairy Pty Ltd., 106 Cameron Rd, Meredith, Victoria 3333, AustraliaMeredith Dairy Pty Ltd., 106 Cameron Rd, Meredith, Victoria 3333, AustraliaMeredith Dairy Pty Ltd., 106 Cameron Rd, Meredith, Victoria 3333, AustraliaMeredith Dairy Pty Ltd., 106 Cameron Rd, Meredith, Victoria 3333, AustraliaSchool of Agriculture, Food and Ecosystem Sciences, Faculty of Science – The University of Melbourne, Parkville, Victoria 3010, AustraliaSchool of Agriculture, Food and Ecosystem Sciences, Faculty of Science – The University of Melbourne, Parkville, Victoria 3010, AustraliaIn dairy operations, antibiotics have traditionally been used to treat, prevent, and control diseases. However, given the mounting global crisis of antimicrobial resistance (AMR), farmers are urged to re-assess and reduce their reliance on antibiotics. Thus, this randomized, double-blinded cohort study aimed to estimate the prevalence of failed and successful transfer of passive immunity (FTPI and STPI) in dairy goat kids reared under commercial conditions, and the effects of antibiotic metaphylaxis on the pre-weaning (≤42 d old) mortality in FTPI and STPI kids. Plasma concentration of immunoglobulin G at 1d old (pIgG-24 h) was measured in 747 male Saanen kids for the determination of FTPI and STPI (pIgG-24 h < 12 and ≥12 g/L, respectively). Kids were then randomly divided into two groups: those receiving a single penicillin injection at 1 d old (PEN), and those receiving no treatment (CTR). The mean (±SD) pIgG-24 h and initial BW (IBW) were 17 ± 9.8 g/L and 4.1 ± 0.64 kg. The prevalence of FTPI was 29% (220/747 kids). Gastrointestinal complications were the primary cause of death (41%), followed by septicemia (22%) and arthritis (17%). A single penicillin injection reduced preweaning mortality by 55% (10 vs 22%, PEN vs CTR). However, results suggest that such a decline was mainly driven by the improved survival rates among FTPI kids, which increased by 19% (from 62% in CTR-FTPI to 82% in PEN-FTPI), as opposed to an 8% increase among STPI kids (from 85% in CTR-STPI to 93% in PEN-STPI). Additionally, the odds of mortality ≤ 42 d old were threefold higher in the CTR-FTPI group when compared to both the CTR-STPI and PEN-FTPI groups, suggesting a potential parity between STPI and PEN for mortality rate reduction. Taken together, the results indicate that although metaphylactic antibiotics can halve preweaning mortality, similar improvements are likely to be achieved via increased STPI rates. Furthermore, by targeting metaphylactic interventions to high-risk groups (i.e., those displaying signs of inadequate colostrum intake and/or low birth BW), farmers could reduce treatment costs and mitigate AMR risks. While these findings carry considerable weight for commercial dairy goat practices, their applicability to other systems (i.e., extensive, semi-intensive, mohair, meat systems) warrants further investigation.http://www.sciencedirect.com/science/article/pii/S1751731123003579Age of deathGrowth performanceImmunoglobulin levelsMetaphylaxisPreweaning mortality |
| spellingShingle | F. Zamuner E.K. Carpenter H. Gebrekidan G. Arcos-Gómez A. Parkinson A.W.N. Cameron B.J. Leury K. DiGiacomo Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids Animal Age of death Growth performance Immunoglobulin levels Metaphylaxis Preweaning mortality |
| title | Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids |
| title_full | Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids |
| title_fullStr | Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids |
| title_full_unstemmed | Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids |
| title_short | Successful transfer of passive immunity: the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids |
| title_sort | successful transfer of passive immunity the natural alternative to antibiotics for boosting the survival of intensively reared dairy goat kids |
| topic | Age of death Growth performance Immunoglobulin levels Metaphylaxis Preweaning mortality |
| url | http://www.sciencedirect.com/science/article/pii/S1751731123003579 |
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