Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

Abstract Background P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour suppressor, and it may represent a novel target for breast cancer treatmen...

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Bibliographic Details
Main Authors: Simon J. Johnston, Dena Ahmad, Mohammed A. Aleskandarany, Sasagu Kurozumi, Chris C. Nolan, Maria Diez-Rodriguez, Andrew R. Green, Emad A. Rakha
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Cancer
Subjects:
Breast cancer
P38
MAPK
Oestrogen receptor
Adjuvant
Survival
Online Access:http://link.springer.com/article/10.1186/s12885-018-4924-2

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