Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women
Background: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women.Method: We went through a registry of spontaneous ICH cases and selected...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.690194/full |
| _version_ | 1818588458764992512 |
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| author | Hao Feng Hao Feng Hao Feng Xin Wang Xin Wang Xin Wang Wenjuan Wang Wenjuan Wang Wenjuan Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao |
| author_facet | Hao Feng Hao Feng Hao Feng Xin Wang Xin Wang Xin Wang Wenjuan Wang Wenjuan Wang Wenjuan Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao |
| author_sort | Hao Feng |
| collection | DOAJ |
| description | Background: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women.Method: We went through a registry of spontaneous ICH cases and selected female patients to study according to our criteria. We collected demographic, clinical, and laboratory information and evaluated serum triglyceride (TG) levels, total cholesterol (TC) levels, low-density cholesterol (LDLC) levels, high-density cholesterol (HDLC) levels, non-high-density cholesterol (non-HDLC) levels, and 3-month modified Rankin Scale (mRS). Multivariate logistic regression was performed, and receiver operating characteristic (ROC) curves were plotted to explore the relationship between serum lipid levels and 3-month ICH clinical outcomes.Results: Two hundred six female patients were included in this study, and 96 (46.6%) of them had poor functional outcomes. In the univariate analysis, low TG (p = 0.006), TC (p = 0.025), LDLC (p = 0.001), non-HDLC (p < 0.001) levels, and high HDL (p = 0.036) levels were associated with poor 3-month clinical outcomes in women. In the multivariate logistic regression, low levels of TG (OR = 0.711, 95% CI = 0.542–0.933, p = 0.014), TC (OR = 0.523, 95% CI = 0.304–0.903, p = 0.020), LDLC (OR = 0.538, 95% CI = 0.307–0.942, p = 0.030), non-HDLC (OR = 0.327, 95% CI = 0.177–0.603, p < 0.001), and a high level of HDLC (OR = 2.075, 95% CI = 1.064–4.047, p = 0.032) with area under the curve (AUC) of 0.610, 0.590, 0.630, 0.645, and 0.415, respectively, remained as independent indicators of poor prognosis at 3 months after adjusting for confounding factors.Conclusion: Low levels of TG, TC, LDLC, non-HDLC, and high levels of HDLC were independently associated with poor prognosis of spontaneous ICH in women. |
| first_indexed | 2024-12-16T09:25:05Z |
| format | Article |
| id | doaj.art-3759c46f32ed4b038c85c5a6c5188c8a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T09:25:05Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-3759c46f32ed4b038c85c5a6c5188c8a2022-12-21T22:36:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-06-011210.3389/fneur.2021.690194690194Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in WomenHao Feng0Hao Feng1Hao Feng2Xin Wang3Xin Wang4Xin Wang5Wenjuan Wang6Wenjuan Wang7Wenjuan Wang8Xingquan Zhao9Xingquan Zhao10Xingquan Zhao11Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, ChinaBackground: The relationship between serum lipids levels and prognosis after spontaneous intracerebral hemorrhage (ICH) is still unclear. We aim to examine the association between lipid levels and 3-month ICH prognosis in women.Method: We went through a registry of spontaneous ICH cases and selected female patients to study according to our criteria. We collected demographic, clinical, and laboratory information and evaluated serum triglyceride (TG) levels, total cholesterol (TC) levels, low-density cholesterol (LDLC) levels, high-density cholesterol (HDLC) levels, non-high-density cholesterol (non-HDLC) levels, and 3-month modified Rankin Scale (mRS). Multivariate logistic regression was performed, and receiver operating characteristic (ROC) curves were plotted to explore the relationship between serum lipid levels and 3-month ICH clinical outcomes.Results: Two hundred six female patients were included in this study, and 96 (46.6%) of them had poor functional outcomes. In the univariate analysis, low TG (p = 0.006), TC (p = 0.025), LDLC (p = 0.001), non-HDLC (p < 0.001) levels, and high HDL (p = 0.036) levels were associated with poor 3-month clinical outcomes in women. In the multivariate logistic regression, low levels of TG (OR = 0.711, 95% CI = 0.542–0.933, p = 0.014), TC (OR = 0.523, 95% CI = 0.304–0.903, p = 0.020), LDLC (OR = 0.538, 95% CI = 0.307–0.942, p = 0.030), non-HDLC (OR = 0.327, 95% CI = 0.177–0.603, p < 0.001), and a high level of HDLC (OR = 2.075, 95% CI = 1.064–4.047, p = 0.032) with area under the curve (AUC) of 0.610, 0.590, 0.630, 0.645, and 0.415, respectively, remained as independent indicators of poor prognosis at 3 months after adjusting for confounding factors.Conclusion: Low levels of TG, TC, LDLC, non-HDLC, and high levels of HDLC were independently associated with poor prognosis of spontaneous ICH in women.https://www.frontiersin.org/articles/10.3389/fneur.2021.690194/fullspontaneous intracerebral hemorrhage3-month prognosiswomentotal cholesterolnon-high-density cholesterollow-density cholesterol |
| spellingShingle | Hao Feng Hao Feng Hao Feng Xin Wang Xin Wang Xin Wang Wenjuan Wang Wenjuan Wang Wenjuan Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women Frontiers in Neurology spontaneous intracerebral hemorrhage 3-month prognosis women total cholesterol non-high-density cholesterol low-density cholesterol |
| title | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
| title_full | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
| title_fullStr | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
| title_full_unstemmed | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
| title_short | Lipid Levels and 3-Month Prognosis After Spontaneous Intracerebral Hemorrhage in Women |
| title_sort | lipid levels and 3 month prognosis after spontaneous intracerebral hemorrhage in women |
| topic | spontaneous intracerebral hemorrhage 3-month prognosis women total cholesterol non-high-density cholesterol low-density cholesterol |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.690194/full |
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