Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode
Fentanyl was successfully determined in the current effort based on hexagonal NiO nanodisks (HG-NiO-NDs) fabricated by the hydrothermal protocol. The synergism of HG-NiO-NDs with multiwall carbon nanotubes (MWCNTs), large specific surface area, and active material enabled the electrochemical sensor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.997662/full |
| _version_ | 1811180015936602112 |
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| author | Xi Li Bo Luo Min Liao Abdullah Mohamed |
| author_facet | Xi Li Bo Luo Min Liao Abdullah Mohamed |
| author_sort | Xi Li |
| collection | DOAJ |
| description | Fentanyl was successfully determined in the current effort based on hexagonal NiO nanodisks (HG-NiO-NDs) fabricated by the hydrothermal protocol. The synergism of HG-NiO-NDs with multiwall carbon nanotubes (MWCNTs), large specific surface area, and active material enabled the electrochemical sensor to show potent electrochemical behavior. Admirable performance was found for the fentanyl measurement by the MWCNT and HG-NiO-ND-modified pencil graphite electrode (MWCNT/HG-NiO-ND/PGE). The correlation of oxidation currents with the pH value, concentration, and sweep rate of supporting electrolytes was determined for the optimization of conditions to detect fentanyl. The surfaces of modified and unmodified electrodes were characterized as well. The diffusion-control processes were confirmed on the basis of anodic peak findings. The results also revealed a two-electron transfer process. The linear range was obtained to be 0.01–800.0 μM for the fentanyl concentrations on the developed electrode, with the sensitivity of 0.1044 μA/mM/cm2. The limit of detection (S/N = 3) was 6.7 nM. The results indicated the ability of the modified electrode to fabricate non-enzymatic fentanyl sensor applications. |
| first_indexed | 2024-04-11T06:43:24Z |
| format | Article |
| id | doaj.art-375a48cee0ee4c96ac02c8017990e4ae |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-11T06:43:24Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Chemistry |
| spelling | doaj.art-375a48cee0ee4c96ac02c8017990e4ae2022-12-22T04:39:24ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-11-011010.3389/fchem.2022.997662997662Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrodeXi Li0Bo Luo1Min Liao2Abdullah Mohamed3Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaResearch Centre, Future University in Egypt, New Cairo, EgyptFentanyl was successfully determined in the current effort based on hexagonal NiO nanodisks (HG-NiO-NDs) fabricated by the hydrothermal protocol. The synergism of HG-NiO-NDs with multiwall carbon nanotubes (MWCNTs), large specific surface area, and active material enabled the electrochemical sensor to show potent electrochemical behavior. Admirable performance was found for the fentanyl measurement by the MWCNT and HG-NiO-ND-modified pencil graphite electrode (MWCNT/HG-NiO-ND/PGE). The correlation of oxidation currents with the pH value, concentration, and sweep rate of supporting electrolytes was determined for the optimization of conditions to detect fentanyl. The surfaces of modified and unmodified electrodes were characterized as well. The diffusion-control processes were confirmed on the basis of anodic peak findings. The results also revealed a two-electron transfer process. The linear range was obtained to be 0.01–800.0 μM for the fentanyl concentrations on the developed electrode, with the sensitivity of 0.1044 μA/mM/cm2. The limit of detection (S/N = 3) was 6.7 nM. The results indicated the ability of the modified electrode to fabricate non-enzymatic fentanyl sensor applications.https://www.frontiersin.org/articles/10.3389/fchem.2022.997662/fullfentanylanesthesia drughexagonal NiO nanodiskspencil graphite electrodevoltammetry |
| spellingShingle | Xi Li Bo Luo Min Liao Abdullah Mohamed Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode Frontiers in Chemistry fentanyl anesthesia drug hexagonal NiO nanodisks pencil graphite electrode voltammetry |
| title | Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode |
| title_full | Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode |
| title_fullStr | Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode |
| title_full_unstemmed | Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode |
| title_short | Electrochemical sensing of fentanyl as an anesthesia drug on NiO nanodisks combined with the carbon nanotube-modified electrode |
| title_sort | electrochemical sensing of fentanyl as an anesthesia drug on nio nanodisks combined with the carbon nanotube modified electrode |
| topic | fentanyl anesthesia drug hexagonal NiO nanodisks pencil graphite electrode voltammetry |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.997662/full |
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