Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study
Introduction: Postoperative pain is one of the main postoperative adverse outcomes following caesarean section. Its management still remains a challenge especially in a low resource setting. Aim: To compare the efficacy of intramuscular pentazocine alone and combined intramuscular pentazocine wi...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9519/25294_CE[Ra1]_F(GH)_PF1(MSGH)_PFA(RK)_PF2(PGGH).pdf |
| _version_ | 1811337444515119104 |
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| author | John Okafor Egede Leonard Ogbonna Ajah Odidika Ugochukwu Umeora Benjamin Chukwuma Ozumba Robinson Chukwudi Onoh Johnson Akuma Obuna Napoleon Ekem |
| author_facet | John Okafor Egede Leonard Ogbonna Ajah Odidika Ugochukwu Umeora Benjamin Chukwuma Ozumba Robinson Chukwudi Onoh Johnson Akuma Obuna Napoleon Ekem |
| author_sort | John Okafor Egede |
| collection | DOAJ |
| description | Introduction: Postoperative pain is one of the main postoperative
adverse outcomes following caesarean section. Its management
still remains a challenge especially in a low resource setting.
Aim: To compare the efficacy of intramuscular pentazocine
alone and combined intramuscular pentazocine with diclofenac
for pain relief within 24 hours after caesarean section.
Materials and Methods: This was a double blind randomized
control study of post caesarean section pain management of
140 participants between April and December, 2015 at the
Federal Teaching hospital, Abakaliki. Inclusion criteria involved
consenting and low risk parturients who had caesarean section
under spinal anaesthesia. The participants were randomly
grouped into Pentazocine-Placebo (PP) group and PentazocineDiclofenac (PD) group. The PP group received pentazocine
30 mg every 4 hours for 24 hours and 3 milliliters of water for
injection as placebo 12 hourly for 24 hours while the PD group
received pentazocine 30 mg every 4 hours and diclofenac 75
mg every 12 hours for 24 hours. The level of pain control was
assessed using the Visual Analog Scale (VAS). The data was
analysed with IBM SPSS version 20.0. The level of significance
was set at < 0.05.
Results: The use of PD for 24 hour post caesarean section
analgesia achieved better pain relief, faster onset of postoperative
ambulation, bowel sound auscultation and oral feeding than the
use of PP (p-value ≤0.002). However, the use of PD is more
expensive than PP (p-value =0.0001). There was no difference
between the two groups of participants on the passage of flatus
and duration of hospital stay (p-value≥0.05). The use of PP was
associated with more maternal side effects (p-value=0.009).
There was no difference on the level of satisfaction between the
two groups of participants (p-value≥0.05).
Conclusion: The use of PD for post caesarean section analgesia
is more effective in achieving a satisfactory pain relief and has
less side effects. |
| first_indexed | 2024-04-13T17:54:58Z |
| format | Article |
| id | doaj.art-375a5760fbb3444eb87d59b876feff85 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T17:54:58Z |
| publishDate | 2017-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-375a5760fbb3444eb87d59b876feff852022-12-22T02:36:33ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-04-01114QC01QC0510.7860/JCDR/2017/25294.9519Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled StudyJohn Okafor Egede0Leonard Ogbonna Ajah1Odidika Ugochukwu Umeora2Benjamin Chukwuma Ozumba3Robinson Chukwudi Onoh4Johnson Akuma Obuna5Napoleon Ekem6Senior Registrar, Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Ebonyi, Nigeria.Senior Lecturer, Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Nigeria, Enugu, Nigeria.Professor, Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Ebonyi, Nigeria.Professor, Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Nigeria, Enugu, Nigeria.Lecturer, Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Ebonyi, Nigeria.Senior Lecturer, Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Ebonyi, Nigeria.Senior Registrar, Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Abakaliki, Ebonyi, Nigeria.Introduction: Postoperative pain is one of the main postoperative adverse outcomes following caesarean section. Its management still remains a challenge especially in a low resource setting. Aim: To compare the efficacy of intramuscular pentazocine alone and combined intramuscular pentazocine with diclofenac for pain relief within 24 hours after caesarean section. Materials and Methods: This was a double blind randomized control study of post caesarean section pain management of 140 participants between April and December, 2015 at the Federal Teaching hospital, Abakaliki. Inclusion criteria involved consenting and low risk parturients who had caesarean section under spinal anaesthesia. The participants were randomly grouped into Pentazocine-Placebo (PP) group and PentazocineDiclofenac (PD) group. The PP group received pentazocine 30 mg every 4 hours for 24 hours and 3 milliliters of water for injection as placebo 12 hourly for 24 hours while the PD group received pentazocine 30 mg every 4 hours and diclofenac 75 mg every 12 hours for 24 hours. The level of pain control was assessed using the Visual Analog Scale (VAS). The data was analysed with IBM SPSS version 20.0. The level of significance was set at < 0.05. Results: The use of PD for 24 hour post caesarean section analgesia achieved better pain relief, faster onset of postoperative ambulation, bowel sound auscultation and oral feeding than the use of PP (p-value ≤0.002). However, the use of PD is more expensive than PP (p-value =0.0001). There was no difference between the two groups of participants on the passage of flatus and duration of hospital stay (p-value≥0.05). The use of PP was associated with more maternal side effects (p-value=0.009). There was no difference on the level of satisfaction between the two groups of participants (p-value≥0.05). Conclusion: The use of PD for post caesarean section analgesia is more effective in achieving a satisfactory pain relief and has less side effects.https://jcdr.net/articles/PDF/9519/25294_CE[Ra1]_F(GH)_PF1(MSGH)_PFA(RK)_PF2(PGGH).pdfmultimodal analgesianigeriapost caesarean sectionunimodal analgesia |
| spellingShingle | John Okafor Egede Leonard Ogbonna Ajah Odidika Ugochukwu Umeora Benjamin Chukwuma Ozumba Robinson Chukwudi Onoh Johnson Akuma Obuna Napoleon Ekem Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study Journal of Clinical and Diagnostic Research multimodal analgesia nigeria post caesarean section unimodal analgesia |
| title | Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study |
| title_full | Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study |
| title_fullStr | Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study |
| title_full_unstemmed | Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study |
| title_short | Pentazocine Alone Versus Pentazocine Plus Diclofenac for Pain Relief in the First 24 Hours after Caesarean Section: A Randomized Controlled Study |
| title_sort | pentazocine alone versus pentazocine plus diclofenac for pain relief in the first 24 hours after caesarean section a randomized controlled study |
| topic | multimodal analgesia nigeria post caesarean section unimodal analgesia |
| url | https://jcdr.net/articles/PDF/9519/25294_CE[Ra1]_F(GH)_PF1(MSGH)_PFA(RK)_PF2(PGGH).pdf |
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