Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia.
To evaluate the effectiveness of high-flow nasal humidified oxygen (HFNHO) therapy in patients with mild hypoxemia after extubation. This study included 316 patients with mild hypoxemia after extubation from May 2016 to May 2018 from two intensive care units in China. Compare the effects of the Vent...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0216957 |
| _version_ | 1818726556646768640 |
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| author | Qiliang Hou Zhigang Zhang Ting Lei Maozhou Gan Xiangjun Wu Weigang Yue Bin Li Lin Deng Hongchang Gong |
| author_facet | Qiliang Hou Zhigang Zhang Ting Lei Maozhou Gan Xiangjun Wu Weigang Yue Bin Li Lin Deng Hongchang Gong |
| author_sort | Qiliang Hou |
| collection | DOAJ |
| description | To evaluate the effectiveness of high-flow nasal humidified oxygen (HFNHO) therapy in patients with mild hypoxemia after extubation. This study included 316 patients with mild hypoxemia after extubation from May 2016 to May 2018 from two intensive care units in China. Compare the effects of the Venturi Mask and High-Flow Nasal Humidified Oxygen (HFNHO) therapy on Heart Rate (HR), Respiratory Rate (RR), Oxygen Saturation (SpO2), Oxygen Partial Pressure (PO2), Partial Pressure Of Carbon Dioxide (PCO2), Oxygenation Index (PO2/FiO2) after extubation, the use of noninvasive mechanical ventilation and tracheal intubation after treatment failure were observed and recorded. Patients have both lower HR and RR than those who received mask treatment (75.4±18.5 vs. 83.0±20.4, p = 0.0004; 18±6.5 vs. 23.6±10.3, p<0.001, respectively). There was significant difference between those who had HFNHO and mask administration's SpO2 and PO2 (94.1±6.4 vs. 87.5±1.5, p<0.001; 88.16±2.9 vs. 77.3±2.3, p<0.001, respectively). For the HFNHO group, patients had lower PCO2 with the mask group. (41.3±0.99 vs 42.2±1.2, p<0.001). On the other hand, the levels of PO2/FiO2 was significantly higher in the HFNHO Group, (181.0±8.3 vs. 157.2±4.9, p<0.05). We concluded HFNHO therapy could significantly relieve the symptoms of dyspnea, improve oxygenation, reduce the use of noninvasive mechanical ventilation and reduce the rate of secondary tracheal intubation in patients with mild hypoxemia after extubation. |
| first_indexed | 2024-12-17T22:00:05Z |
| format | Article |
| id | doaj.art-375b08dbcbbe45febcb1a797a01fbd0a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T22:00:05Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-375b08dbcbbe45febcb1a797a01fbd0a2022-12-21T21:31:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01146e021695710.1371/journal.pone.0216957Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia.Qiliang HouZhigang ZhangTing LeiMaozhou GanXiangjun WuWeigang YueBin LiLin DengHongchang GongTo evaluate the effectiveness of high-flow nasal humidified oxygen (HFNHO) therapy in patients with mild hypoxemia after extubation. This study included 316 patients with mild hypoxemia after extubation from May 2016 to May 2018 from two intensive care units in China. Compare the effects of the Venturi Mask and High-Flow Nasal Humidified Oxygen (HFNHO) therapy on Heart Rate (HR), Respiratory Rate (RR), Oxygen Saturation (SpO2), Oxygen Partial Pressure (PO2), Partial Pressure Of Carbon Dioxide (PCO2), Oxygenation Index (PO2/FiO2) after extubation, the use of noninvasive mechanical ventilation and tracheal intubation after treatment failure were observed and recorded. Patients have both lower HR and RR than those who received mask treatment (75.4±18.5 vs. 83.0±20.4, p = 0.0004; 18±6.5 vs. 23.6±10.3, p<0.001, respectively). There was significant difference between those who had HFNHO and mask administration's SpO2 and PO2 (94.1±6.4 vs. 87.5±1.5, p<0.001; 88.16±2.9 vs. 77.3±2.3, p<0.001, respectively). For the HFNHO group, patients had lower PCO2 with the mask group. (41.3±0.99 vs 42.2±1.2, p<0.001). On the other hand, the levels of PO2/FiO2 was significantly higher in the HFNHO Group, (181.0±8.3 vs. 157.2±4.9, p<0.05). We concluded HFNHO therapy could significantly relieve the symptoms of dyspnea, improve oxygenation, reduce the use of noninvasive mechanical ventilation and reduce the rate of secondary tracheal intubation in patients with mild hypoxemia after extubation.https://doi.org/10.1371/journal.pone.0216957 |
| spellingShingle | Qiliang Hou Zhigang Zhang Ting Lei Maozhou Gan Xiangjun Wu Weigang Yue Bin Li Lin Deng Hongchang Gong Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia. PLoS ONE |
| title | Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia. |
| title_full | Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia. |
| title_fullStr | Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia. |
| title_full_unstemmed | Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia. |
| title_short | Clinical efficacy of high-flow nasal humidified oxygen therapy in patients with hypoxemia. |
| title_sort | clinical efficacy of high flow nasal humidified oxygen therapy in patients with hypoxemia |
| url | https://doi.org/10.1371/journal.pone.0216957 |
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