The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats
Olfaction, the sense of smell, plays an important role in the individual's safety, nutrition, social interactions, sexual function, and quality of life. Diabetes mellitus, which affects more than 400 million people worldwide, is associated with olfactory dysfunction. This work evaluated the olf...
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| Format: | Article |
| Language: | English |
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Kharazmi University
2023-06-01
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| Series: | یافتههای نوین در علوم زیستی |
| Subjects: | |
| Online Access: | http://nbr.khu.ac.ir/article-1-3550-en.pdf |
| _version_ | 1797795165699571712 |
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| author | Hamidreza Yahyaeipour Farzaneh Ganji Hamid Sepehri Zahra Nazari |
| author_facet | Hamidreza Yahyaeipour Farzaneh Ganji Hamid Sepehri Zahra Nazari |
| author_sort | Hamidreza Yahyaeipour |
| collection | DOAJ |
| description | Olfaction, the sense of smell, plays an important role in the individual's safety, nutrition, social interactions, sexual function, and quality of life. Diabetes mellitus, which affects more than 400 million people worldwide, is associated with olfactory dysfunction. This work evaluated the olfactory bulb structure of Type 2 diabetes rats. Type 2 diabetes induction was performed by administering 20mg/Kg Streptozotocin to adult Wistar rats for five days. 35 days after injection, animals were sacrificed, and olfactory bulb tissue was harvested for tissue processing and Nissl staining to evaluate the olfactory bulb structure. Based on the results, diabetic animals showed a significant decrease in the Glomeruli number compared to controls (P<0.05). Furthermore, we observed a significant decrease in the internal plexiform layer thickness in the olfactory bulb of diabetic rats when compared to controls (P<0.05). The present results showed that olfactory dysfunction in Type 2 diabetes rats is associated with olfactory bulb structural change, which indicates the olfactory bulb tissue damage caused by diabetes. |
| first_indexed | 2024-03-13T03:13:46Z |
| format | Article |
| id | doaj.art-375c18d9f55b40abbb70c951e8074437 |
| institution | Directory Open Access Journal |
| issn | 2423-6330 2476-7115 |
| language | English |
| last_indexed | 2024-03-13T03:13:46Z |
| publishDate | 2023-06-01 |
| publisher | Kharazmi University |
| record_format | Article |
| series | یافتههای نوین در علوم زیستی |
| spelling | doaj.art-375c18d9f55b40abbb70c951e80744372023-06-26T05:19:46ZengKharazmi Universityیافتههای نوین در علوم زیستی2423-63302476-71152023-06-011011116The effect of type 2 diabetes on the olfactory bulb structure of Wistar ratsHamidreza Yahyaeipour0Farzaneh Ganji1Hamid Sepehri2Zahra Nazari3 Department of Biology, School of Sciences, Golestan University, Gorgan, Iran Department of Biology, School of Sciences, Golestan University, Gorgan, Iran Department of Physiology, Neuroscience Research Center, Golestan University of Medical Science, Gorgan, Iran Department of Biology, School of Sciences, Golestan University, Gorgan, Iran Olfaction, the sense of smell, plays an important role in the individual's safety, nutrition, social interactions, sexual function, and quality of life. Diabetes mellitus, which affects more than 400 million people worldwide, is associated with olfactory dysfunction. This work evaluated the olfactory bulb structure of Type 2 diabetes rats. Type 2 diabetes induction was performed by administering 20mg/Kg Streptozotocin to adult Wistar rats for five days. 35 days after injection, animals were sacrificed, and olfactory bulb tissue was harvested for tissue processing and Nissl staining to evaluate the olfactory bulb structure. Based on the results, diabetic animals showed a significant decrease in the Glomeruli number compared to controls (P<0.05). Furthermore, we observed a significant decrease in the internal plexiform layer thickness in the olfactory bulb of diabetic rats when compared to controls (P<0.05). The present results showed that olfactory dysfunction in Type 2 diabetes rats is associated with olfactory bulb structural change, which indicates the olfactory bulb tissue damage caused by diabetes.http://nbr.khu.ac.ir/article-1-3550-en.pdfdiabetes mellitusglomerulinissl stainingsense of smellstreptozotocin |
| spellingShingle | Hamidreza Yahyaeipour Farzaneh Ganji Hamid Sepehri Zahra Nazari The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats یافتههای نوین در علوم زیستی diabetes mellitus glomeruli nissl staining sense of smell streptozotocin |
| title | The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats |
| title_full | The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats |
| title_fullStr | The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats |
| title_full_unstemmed | The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats |
| title_short | The effect of type 2 diabetes on the olfactory bulb structure of Wistar rats |
| title_sort | effect of type 2 diabetes on the olfactory bulb structure of wistar rats |
| topic | diabetes mellitus glomeruli nissl staining sense of smell streptozotocin |
| url | http://nbr.khu.ac.ir/article-1-3550-en.pdf |
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