Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells

Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells

Glioblastoma (GBM) stem cells (GSCs), which contribute to GBM unfavorable prognosis, show high expression levels of ATP/P2X7 receptors (P2X7R). Here, we reported that cells exposure to 2&#8217;(3&#8217;)-<i>O</i>-(4-benzoylbenzoyl)-ATP (BzATP), a P2X7R agonist, up-regulated the e...

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Bibliographic Details
Main Authors: Sihana Ziberi, Mariachiara Zuccarini, Marzia Carluccio, Patricia Giuliani, Lucia Ricci-Vitiani, Roberto Pallini, Francesco Caciagli, Patrizia Di Iorio, Renata Ciccarelli
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
glioblastoma stem cells (gscs)
epithelial-to-mesenchymal transition (emt) markers
gsc invasiveness
transforming growth factor beta
bzatp
p2x7 receptor splice variants a and b
Online Access:https://www.mdpi.com/2073-4409/9/1/85

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