Hematological Findings in Children with Serum Vitamin B12 Deficiency
Aim: Vitamin B12 is essential for DNA synthesis and hematopoiesis, and its severe deficiency not only causes anemia, but may also result in thrombocytopenia and leucopenia. In this study, we analysed the relationship between hematological status and vitamin B12 deficiency and draw attention to this...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Rabia Yılmaz
2021-05-01
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| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1591444 |
| _version_ | 1797860606554931200 |
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| author | Mustafa Örkmez Hatice Tuba Akbayram |
| author_facet | Mustafa Örkmez Hatice Tuba Akbayram |
| author_sort | Mustafa Örkmez |
| collection | DOAJ |
| description | Aim: Vitamin B12 is essential for DNA synthesis and hematopoiesis, and its severe deficiency not only causes anemia, but may also result in thrombocytopenia and leucopenia. In this study, we analysed the relationship between hematological status and vitamin B12 deficiency and draw attention to this issue.
Material and Method: The data gathered from our institute Gaziantep University Hospital outpatient clinics electronic database. Six hundred forty children were evaluated. The inclusion criteria were child patients with less than 200 ng/l vitamin B12 levels.
Results: Four hundred seventy-seven patients (74.5%) had no hematological abnormalities. Anemia was detected in 99 patients (15.5 %), two patients (0.3%) had a Hb-level lt; 7 g/dl, anemia without macrocytosis in 91 (14.2 %), anemia with macrocytosis in 8 (1.3 %), leucopenia in 8 (1.3 %), neutropenia in 22 (3.4 %), lymphopenia in 9 (1.4 %), thrombocytopenia in 6 (0.9 %), and pancytopenia in 3 patients (0.4 %). An examination of the correlation, there were no correlations between vitamin B12 levels and hematological parameters.
Conclusion: Our results showed that hematological abnormalities were detected in only 25.5% of patients with Vitamin B12 deficiency, and anemia and neutropenia were the most common hematological abnormalities. In addition, serum vitamin B12 levels were not significantly correlated with the complete blood count parameters. |
| first_indexed | 2024-04-09T21:49:38Z |
| format | Article |
| id | doaj.art-376090445acf43889080d8a8e47f4f2c |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:49:38Z |
| publishDate | 2021-05-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-376090445acf43889080d8a8e47f4f2c2023-03-24T19:43:25ZengRabia YılmazJournal of Contemporary Medicine2667-71802021-05-0111329429710.16899/jcm.8840681809Hematological Findings in Children with Serum Vitamin B12 DeficiencyMustafa Örkmez0Hatice Tuba Akbayram1GAZİANTEP ÜNİVERSİTESİ, GAZİANTEP MESLEK YÜKSEKOKULUGaziantep Üniversitesi Tıp Fakültesi Aile Hekimliği Anabilim DalıAim: Vitamin B12 is essential for DNA synthesis and hematopoiesis, and its severe deficiency not only causes anemia, but may also result in thrombocytopenia and leucopenia. In this study, we analysed the relationship between hematological status and vitamin B12 deficiency and draw attention to this issue. Material and Method: The data gathered from our institute Gaziantep University Hospital outpatient clinics electronic database. Six hundred forty children were evaluated. The inclusion criteria were child patients with less than 200 ng/l vitamin B12 levels. Results: Four hundred seventy-seven patients (74.5%) had no hematological abnormalities. Anemia was detected in 99 patients (15.5 %), two patients (0.3%) had a Hb-level lt; 7 g/dl, anemia without macrocytosis in 91 (14.2 %), anemia with macrocytosis in 8 (1.3 %), leucopenia in 8 (1.3 %), neutropenia in 22 (3.4 %), lymphopenia in 9 (1.4 %), thrombocytopenia in 6 (0.9 %), and pancytopenia in 3 patients (0.4 %). An examination of the correlation, there were no correlations between vitamin B12 levels and hematological parameters. Conclusion: Our results showed that hematological abnormalities were detected in only 25.5% of patients with Vitamin B12 deficiency, and anemia and neutropenia were the most common hematological abnormalities. In addition, serum vitamin B12 levels were not significantly correlated with the complete blood count parameters.https://dergipark.org.tr/tr/download/article-file/1591444vitamin b12,anemia,neutropeniaanemivitamin b12nötropeni |
| spellingShingle | Mustafa Örkmez Hatice Tuba Akbayram Hematological Findings in Children with Serum Vitamin B12 Deficiency Journal of Contemporary Medicine vitamin b12, anemia, neutropenia anemi vitamin b12 nötropeni |
| title | Hematological Findings in Children with Serum Vitamin B12 Deficiency |
| title_full | Hematological Findings in Children with Serum Vitamin B12 Deficiency |
| title_fullStr | Hematological Findings in Children with Serum Vitamin B12 Deficiency |
| title_full_unstemmed | Hematological Findings in Children with Serum Vitamin B12 Deficiency |
| title_short | Hematological Findings in Children with Serum Vitamin B12 Deficiency |
| title_sort | hematological findings in children with serum vitamin b12 deficiency |
| topic | vitamin b12, anemia, neutropenia anemi vitamin b12 nötropeni |
| url | https://dergipark.org.tr/tr/download/article-file/1591444 |
| work_keys_str_mv | AT mustafaorkmez hematologicalfindingsinchildrenwithserumvitaminb12deficiency AT haticetubaakbayram hematologicalfindingsinchildrenwithserumvitaminb12deficiency |