Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma
Abstract Background Pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma sometimes presents as large pulmonary nodules composed of small nodular opacities (galaxy sign) on computed tomography (CT). The aim of this study was to assess the presence, usefulness, and pathological characteristics...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
|
| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.15029 |
| _version_ | 1797738171749892096 |
|---|---|
| author | Yeongran Song Yeoun Eun Sung Kyongmin S. Beck Suyon Chang Jung Im Jung Gyeong Sin Park |
| author_facet | Yeongran Song Yeoun Eun Sung Kyongmin S. Beck Suyon Chang Jung Im Jung Gyeong Sin Park |
| author_sort | Yeongran Song |
| collection | DOAJ |
| description | Abstract Background Pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma sometimes presents as large pulmonary nodules composed of small nodular opacities (galaxy sign) on computed tomography (CT). The aim of this study was to assess the presence, usefulness, and pathological characteristics of the galaxy sign on CT of pulmonary MALT lymphoma. Methods From January 2011 to December 2021, chest CTs of 43 patients with pulmonary MALT lymphoma were reviewed by two radiologists for the galaxy sign and various other findings. Interreader agreement to characterize the galaxy sign and factors associated in making a correct first impression on CT prior to pathological diagnosis were assessed. Resected specimens were reviewed by two pathologists, and the proportion of peripheral lymphoma infiltrates was compared between lesions with and without the galaxy sign. Results Of 43 patients, 22 patients (44.2%) showed the galaxy sign (κ = 0.768, p < 0.0001). The galaxy sign (p = 0.010) was associated with making a correct first impression on CT prior to pathological diagnosis. On pathological examination, lesions showing the galaxy sign on CT demonstrated a significantly higher proportion of peripheral lymphoma infiltrates (p = 0.001). Conclusion The galaxy sign can be seen on CT of pulmonary MALT lymphoma with a higher proportion of peripheral lymphoma infiltrates and may be useful in making a correct diagnosis of pulmonary MALT lymphoma. |
| first_indexed | 2024-03-12T13:39:14Z |
| format | Article |
| id | doaj.art-3762087904144044a46ba538151d745a |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-12T13:39:14Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-3762087904144044a46ba538151d745a2023-08-23T23:56:30ZengWileyThoracic Cancer1759-77061759-77142023-08-0114242459246610.1111/1759-7714.15029Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphomaYeongran Song0Yeoun Eun Sung1Kyongmin S. Beck2Suyon Chang3Jung Im Jung4Gyeong Sin Park5Department of Radiology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Radiology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Radiology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Radiology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea Seoul Republic of KoreaAbstract Background Pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma sometimes presents as large pulmonary nodules composed of small nodular opacities (galaxy sign) on computed tomography (CT). The aim of this study was to assess the presence, usefulness, and pathological characteristics of the galaxy sign on CT of pulmonary MALT lymphoma. Methods From January 2011 to December 2021, chest CTs of 43 patients with pulmonary MALT lymphoma were reviewed by two radiologists for the galaxy sign and various other findings. Interreader agreement to characterize the galaxy sign and factors associated in making a correct first impression on CT prior to pathological diagnosis were assessed. Resected specimens were reviewed by two pathologists, and the proportion of peripheral lymphoma infiltrates was compared between lesions with and without the galaxy sign. Results Of 43 patients, 22 patients (44.2%) showed the galaxy sign (κ = 0.768, p < 0.0001). The galaxy sign (p = 0.010) was associated with making a correct first impression on CT prior to pathological diagnosis. On pathological examination, lesions showing the galaxy sign on CT demonstrated a significantly higher proportion of peripheral lymphoma infiltrates (p = 0.001). Conclusion The galaxy sign can be seen on CT of pulmonary MALT lymphoma with a higher proportion of peripheral lymphoma infiltrates and may be useful in making a correct diagnosis of pulmonary MALT lymphoma.https://doi.org/10.1111/1759-7714.15029computed tomographygalaxy signMALT lymphomamarginal zone B cell lymphoma |
| spellingShingle | Yeongran Song Yeoun Eun Sung Kyongmin S. Beck Suyon Chang Jung Im Jung Gyeong Sin Park Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma Thoracic Cancer computed tomography galaxy sign MALT lymphoma marginal zone B cell lymphoma |
| title | Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma |
| title_full | Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma |
| title_fullStr | Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma |
| title_full_unstemmed | Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma |
| title_short | Radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa‐associated lymphoid tissue (MALT) lymphoma |
| title_sort | radiological and pathological analysis of the galaxy sign in patients with pulmonary mucosa associated lymphoid tissue malt lymphoma |
| topic | computed tomography galaxy sign MALT lymphoma marginal zone B cell lymphoma |
| url | https://doi.org/10.1111/1759-7714.15029 |
| work_keys_str_mv | AT yeongransong radiologicalandpathologicalanalysisofthegalaxysigninpatientswithpulmonarymucosaassociatedlymphoidtissuemaltlymphoma AT yeouneunsung radiologicalandpathologicalanalysisofthegalaxysigninpatientswithpulmonarymucosaassociatedlymphoidtissuemaltlymphoma AT kyongminsbeck radiologicalandpathologicalanalysisofthegalaxysigninpatientswithpulmonarymucosaassociatedlymphoidtissuemaltlymphoma AT suyonchang radiologicalandpathologicalanalysisofthegalaxysigninpatientswithpulmonarymucosaassociatedlymphoidtissuemaltlymphoma AT jungimjung radiologicalandpathologicalanalysisofthegalaxysigninpatientswithpulmonarymucosaassociatedlymphoidtissuemaltlymphoma AT gyeongsinpark radiologicalandpathologicalanalysisofthegalaxysigninpatientswithpulmonarymucosaassociatedlymphoidtissuemaltlymphoma |