Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.)
The purpose of the work is to study antitumor activity of flavonoid-containing extracts of anthocyan maize and gratiola in experiments in vivo and to estimate their effects on the internal organs, tumors and blood of rats with transplanted liver cancer PC-1. Materials and methods: Effect of extracts...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Saratov State Medical University
2013-06-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/2013-02_213-220.pdf |
| _version_ | 1819008954097729536 |
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| author | Navolokin N.A. Polukonova N.V. Maslyakova G.N. Bucharskaya А.В. Durnova N.A. |
| author_facet | Navolokin N.A. Polukonova N.V. Maslyakova G.N. Bucharskaya А.В. Durnova N.A. |
| author_sort | Navolokin N.A. |
| collection | DOAJ |
| description | The purpose of the work is to study antitumor activity of flavonoid-containing extracts of anthocyan maize and gratiola in experiments in vivo and to estimate their effects on the internal organs, tumors and blood of rats with transplanted liver cancer PC-1. Materials and methods: Effect of extracts of anthocyan maize and gratiola has been studied in experiments in vivo in 30 laboratory rats with transplanted liver cancer PC-1 using morphological and biochemical methods. Results: It has been found that extract of gratiola received by a certain way has selective cytotoxic effect on tumor cells. Anthocyan maize extract reduces endogenous intoxication. Conclusion: These results open the prospect of further study of the extract of gratiola in various experimental models of cancer and anthocyan maize extract use may be developed as a means of endogenous intoxication reducing for application in the treatment of cancer. Investigation of anthocyan maize extract may assist in the development of drugs that reduce the endogenous intoxication at the treatment of cancer. |
| first_indexed | 2024-12-21T00:48:40Z |
| format | Article |
| id | doaj.art-376223c5edcd48bfba9283ec10b65b1d |
| institution | Directory Open Access Journal |
| issn | 1995-0039 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-21T00:48:40Z |
| publishDate | 2013-06-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-376223c5edcd48bfba9283ec10b65b1d2022-12-21T19:21:28ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182013-06-0192213220Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.)Navolokin N.A.Polukonova N.V.Maslyakova G.N.Bucharskaya А.В.Durnova N.A.The purpose of the work is to study antitumor activity of flavonoid-containing extracts of anthocyan maize and gratiola in experiments in vivo and to estimate their effects on the internal organs, tumors and blood of rats with transplanted liver cancer PC-1. Materials and methods: Effect of extracts of anthocyan maize and gratiola has been studied in experiments in vivo in 30 laboratory rats with transplanted liver cancer PC-1 using morphological and biochemical methods. Results: It has been found that extract of gratiola received by a certain way has selective cytotoxic effect on tumor cells. Anthocyan maize extract reduces endogenous intoxication. Conclusion: These results open the prospect of further study of the extract of gratiola in various experimental models of cancer and anthocyan maize extract use may be developed as a means of endogenous intoxication reducing for application in the treatment of cancer. Investigation of anthocyan maize extract may assist in the development of drugs that reduce the endogenous intoxication at the treatment of cancer.http://www.ssmj.ru/system/files/2013-02_213-220.pdfbioflavonoidextractGratiola officinalisliver cancertoxicityZea mays |
| spellingShingle | Navolokin N.A. Polukonova N.V. Maslyakova G.N. Bucharskaya А.В. Durnova N.A. Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) Саратовский научно-медицинский журнал bioflavonoid extract Gratiola officinalis liver cancer toxicity Zea mays |
| title | Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) |
| title_full | Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) |
| title_fullStr | Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) |
| title_full_unstemmed | Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) |
| title_short | Internal organs morphology and tumors in laboratory rats with transplanted liver cancer PC-1 by oral intoduction containing extract of Gratiola (Gratiola Officinalis L.) and Anthocyan Maize (Zea Mays L.) |
| title_sort | internal organs morphology and tumors in laboratory rats with transplanted liver cancer pc 1 by oral intoduction containing extract of gratiola gratiola officinalis l and anthocyan maize zea mays l |
| topic | bioflavonoid extract Gratiola officinalis liver cancer toxicity Zea mays |
| url | http://www.ssmj.ru/system/files/2013-02_213-220.pdf |
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